AG-24322

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Search structure


Synonyms	AG-024322 Ag 024322 Ag-24322
Status
Molecule Category	Free-form
UNII	926F8X7TNO

Structure


InChI Key	RBOKLZGCVRXGEP-XTQSDGFTSA-N
Smiles	CCNCc1cncc(-c2ccc3c(c2)/C(=C2/N=c4cc(F)cc(F)c4=N2)NN3)c1C
InChI	InChI=1S/C23H20F2N6/c1-3-26-9-14-10-27-11-17(12(14)2)13-4-5-19-16(6-13)21(31-30-19)23-28-20-8-15(24)7-18(25)22(20)29-23/h4-8,10-11,26,30-31H,3,9H2,1-2H3/b23-21+

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H20F2N6
Molecular Weight	418.45
AlogP	2.95
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	4.0
Polar Surface Area	73.7
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	31.0

Pharmacology

Mechanism of Action	Action	Reference
Cyclin-dependent kinase 1 inhibitor	INHIBITOR	PubMed Other

Target Conservation


Protein: Cyclin-dependent kinase 1 Description: Cyclin-dependent kinase 1 Organism : Homo sapiens P06493 ENSG00000170312














Protein: Cyclin-dependent kinase 4 Description: Cyclin-dependent kinase 4 Organism : Homo sapiens P11802 ENSG00000135446












Protein: Cyclin-dependent kinase 2 Description: Cyclin-dependent kinase 2 Organism : Homo sapiens P24941 ENSG00000123374

Cross References

Resources	Reference
ChEMBL	CHEMBL3545420
FDA SRS	926F8X7TNO
PubChem	135413565
ZINC	ZINC000038192608

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025