SURAMIN HEXASODIUM

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Salt-form
UNII 89521262IH
EPA CompTox DTXSID30156024

Structure

InChI Key VAPNKLKDKUDFHK-UHFFFAOYSA-H
Smiles Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)[O-])c3cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)[O-])c5cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c45)ccc3C)c2)c1.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChI
InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6

Physicochemical Descriptors

Property Name Value
Molecular Formula C51H34N6Na6O23S6
Molecular Weight 1429.19

Pharmacology

Mechanism of Action Action Reference
Acidic fibroblast growth factor inhibitor INHIBITOR PubMed PubMed PubMed PubMed PubMed PubChem
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C1A family
- - - - 31.5
Epigenetic regulator Eraser Histone deacetylase HDAC class III
- 300 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Leukotriene receptor
- - - - 33
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Purine receptor
- - - - 15
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- - - - 15-33
Norovirus
27 - - - -
Trypanosoma brucei
- 43 - - -
Trypanosoma brucei brucei
- 300-310 - - -
Trypanosoma brucei rhodesiense
- - - - 31.5

Cross References

Resources Reference
ChEBI 9364
ChEMBL CHEMBL413376
FDA SRS 89521262IH
SureChEMBL SCHEMBL414636
CONTENTS