TEGLARINAD CHLORIDE

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Search structure


Synonyms	EB-1627 EB1627 GMX-1777 GMX1777 Teglarinad chloride
Status
Molecule Category	Salt-form
UNII	D6V5QYX9MZ
EPA CompTox	DTXSID50962962

Structure


InChI Key	DAHMXVAETAAQOZ-UHFFFAOYSA-N
Smiles	COCCOCCOCCOCCOC(=O)OC[n+]1ccc(N/C(=N/C#N)NCCCCCCOc2ccc(Cl)cc2)cc1.[Cl-]
InChI	InChI=1S/C30H42ClN5O8.ClH/c1-38-16-17-39-18-19-40-20-21-41-22-23-43-30(37)44-25-36-13-10-27(11-14-36)35-29(34-24-32)33-12-4-2-3-5-15-42-28-8-6-26(31)7-9-28;/h6-11,13-14H,2-5,12,15-23,25H2,1H3,(H,33,34);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C30H43Cl2N5O8
Molecular Weight	672.61
AlogP	3.91
Hydrogen Bond Acceptor	10.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	23.0
Polar Surface Area	145.77
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	44.0

Pharmacology

Mechanism of Action	Action	Reference
Nicotinamide phosphoribosyltransferase inhibitor	INHIBITOR	PubMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.7943	-	-	-

Target Conservation


Protein: Nicotinamide phosphoribosyltransferase Description: Nicotinamide phosphoribosyltransferase Organism : Homo sapiens P43490 ENSG00000105835

Cross References

Resources	Reference
CAS NUMBER	432037-57-5
ChEMBL	CHEMBL190412
FDA SRS	D6V5QYX9MZ
PubChem	9961434
SureChEMBL	SCHEMBL2672343

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 23^rd March 2026