TOREFORANT

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Search structure


Synonyms	JNJ-38518168 Jnj-38518168 Toreforant
Status
Molecule Category	Free-form
UNII	U6LA7G393X

Structure


InChI Key	FCRFVPZAXGJLPW-UHFFFAOYSA-N
Smiles	Cc1cc(C)c2nc(-c3cnc(NCCCC4CCN(C)CC4)nc3C)[nH]c2c1
InChI	InChI=1S/C23H32N6/c1-15-12-16(2)21-20(13-15)27-22(28-21)19-14-25-23(26-17(19)3)24-9-5-6-18-7-10-29(4)11-8-18/h12-14,18H,5-11H2,1-4H3,(H,27,28)(H,24,25,26)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H32N6
Molecular Weight	392.55
AlogP	4.48
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	69.73
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	29.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H4 receptor antagonist	ANTAGONIST	PubMed

Target Conservation


Protein: Histamine H4 receptor Description: Histamine H4 receptor Organism : Homo sapiens Q9H3N8 ENSG00000134489

Cross References

Resources	Reference
ChEMBL	CHEMBL3301609
DrugBank	DB12522
FDA SRS	U6LA7G393X
Guide to Pharmacology	9276
PubChem	23650961
SureChEMBL	SCHEMBL1535698

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025