FIBOFLAPON SODIUM

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Search structure


Synonyms	AM-803 SODIUM Am803 sodium Fiboflapon sodium GSK-2190915A GSK2190915A SODIUM SALT
Status
Molecule Category	Salt-form
UNII	75YS00XOG3
EPA CompTox	DTXSID50152523

Structure


InChI Key	NOJNFULGOQGBKB-UHFFFAOYSA-M
Smiles	CCOc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)[O-])c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)cn1.[Na+]
InChI	InChI=1S/C38H43N3O4S.Na/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3,4)5)33(41)20-38(6,7)36(42)43;/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43);/q;+1/p-1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C38H42N3NaO4S
Molecular Weight	659.83
AlogP	8.98
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	12.0
Polar Surface Area	86.47
Molecular species	ACID
Aromatic Rings	5.0
Heavy Atoms	46.0

Pharmacology

Mechanism of Action	Action	Reference
5-lipoxygenase activating protein inhibitor	INHIBITOR	PubMed PubMed

Target Conservation


Protein: 5-lipoxygenase activating protein Description: Arachidonate 5-lipoxygenase-activating protein Organism : Homo sapiens P20292 ENSG00000132965

Cross References

Resources	Reference
ChEMBL	CHEMBL1922673
FDA SRS	75YS00XOG3
PubChem	44473150
SureChEMBL	SCHEMBL1254527

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025