EcoDrugPlus


Synonyms	Aminodeoxykanamycin Bekanamycin Bekanamycin sulfate Kanamycin b Kantrex Klebcil NK 1006 NK-1006 Nebramycin v
Status
Molecule Category	Free-form
ATC	J01GB13
UNII	15JT14C3GI
EPA CompTox	DTXSID8023185


InChI Key	SKKLOUVUUNMCJE-FQSMHNGLSA-N
Smiles	NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O
InChI	InChI=1S/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1

Property Name	Value
Molecular Formula	C18H37N5O10
Molecular Weight	483.52
AlogP	-7.33
Hydrogen Bond Acceptor	15.0
Hydrogen Bond Donor	11.0
Number of Rotational Bond	6.0
Polar Surface Area	288.4
Molecular species	BASE
Aromatic Rings	0.0
Heavy Atoms	33.0

Mechanism of Action	Action	Reference
Bacterial 70S ribosome inhibitor	INHIBITOR	PubMed PubMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Escherichia coli	300-300	40	-	-	-

Resources	Reference
ChEBI	28098
ChEMBL	CHEMBL176
DrugBank	DB13673
DrugCentral	1520
FDA SRS	15JT14C3GI
KEGG	C00825
PDB	9CS
PubChem	439318
SureChEMBL	SCHEMBL158426
ZINC	ZINC000053132258

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

BEKANAMYCIN

Structure

Physicochemical Descriptors

Pharmacology

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