ONO-2333MS

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form

Structure

InChI Key LDIOUQIXNSSOGU-UHFFFAOYSA-N
Smiles CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)CCC2
InChI
InChI=1S/C22H27ClN4O/c1-5-14(6-2)24-21-17-8-7-9-19(17)25-22-20(13(3)26-27(21)22)16-11-10-15(28-4)12-18(16)23/h10-12,14,24H,5-9H2,1-4H3

Pharmacology

Mechanism of Action Action Reference
Corticotropin releasing factor receptor 1 antagonist ANTAGONIST PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) Corticotropin releasing factor receptor Corticotropin releasing factor receptor
40-40 4-7 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
40 4 - - -
Rattus norvegicus
40 7 - - -

Target Conservation

Protein: Corticotropin releasing factor receptor 1
Description: Corticotropin-releasing factor receptor 1
Organism : Homo sapiens
P34998 ENSG00000120088

Cross References

Resources Reference
ChEMBL CHEMBL3545034
CONTENTS