NAFTIFINE

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Search structure


Synonyms	AW-105-843 Naft-500 Naftifine
Status
Molecule Category	Free-form
ATC	D01AE22
UNII	4FB1TON47A
EPA CompTox	DTXSID6048545

Structure


InChI Key	OZGNYLLQHRPOBR-DHZHZOJOSA-N
Smiles	CN(C/C=C/c1ccccc1)Cc1cccc2ccccc12
InChI	InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H21N
Molecular Weight	287.41
AlogP	4.99
Hydrogen Bond Acceptor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	3.24
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	22.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Isomerase	-	-	-	310	-
Membrane receptor	-	-	-	880	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Candida albicans	-	469	-	-	-
Candida albicans SC5314	-	284	-	-	-
Cavia porcellus	-	-	-	880	-
Saccharomyces cerevisiae	-	-	-	310	-

Cross References

Resources	Reference
ChEBI	7451
ChEMBL	CHEMBL626
DrugCentral	1872
FDA SRS	4FB1TON47A
KEGG	C08071
PharmGKB	PA164748617
PubChem	47641
SureChEMBL	SCHEMBL49141
ZINC	ZINC000001530977

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025