EcoDrugPlus


Synonyms	Dl-4-hydroxyamphetamine Dl-p-hydroxyamphetamine Hydroxyamfetamine Hydroxyamphetamine NSC-170995 Norveritol P-hydroxyamphetamine Phenol, p-(2-aminopropyl)- Pulsoton Racemic p-hydroxyamphetamine
Status
Molecule Category	Free-form
UNII	FQR280JW2N
EPA CompTox	DTXSID3023134


InChI Key	GIKNHHRFLCDOEU-UHFFFAOYSA-N
Smiles	CC(N)Cc1ccc(O)cc1
InChI	InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3

Property Name	Value
Molecular Formula	C9H13NO
Molecular Weight	151.21
AlogP	1.28
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	46.25
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	11.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Trace amine receptor	50-51	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Rattus norvegicus	50-51	-	-	-	-

Resources	Reference
ChEBI	103855
ChEMBL	CHEMBL1546
DrugBank	DB09352
DrugCentral	1394
FDA SRS	FQR280JW2N
Human Metabolome Database	HMDB0060765
PubChem	3651
SureChEMBL	SCHEMBL125440

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

HYDROXYAMPHETAMINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References