AC-430

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Search structure


Synonyms	AC430 Ac-430
Status
Molecule Category	Free-form
UNII	E7YVO9NSJ9

Structure


InChI Key	DCRWIATZWHLIPN-UHFFFAOYSA-N
Smiles	Cc1cc(Nc2nc(C(O)c3ccc(F)cc3)nc3ccccc23)n[nH]1
InChI	InChI=1S/C19H16FN5O/c1-11-10-16(25-24-11)22-18-14-4-2-3-5-15(14)21-19(23-18)17(26)12-6-8-13(20)9-7-12/h2-10,17,26H,1H3,(H2,21,22,23,24,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H16FN5O
Molecular Weight	349.37
AlogP	3.63
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	4.0
Polar Surface Area	86.72
Molecular species	NEUTRAL
Aromatic Rings	4.0
Heavy Atoms	26.0

Pharmacology

Mechanism of Action	Action	Reference
Tyrosine-protein kinase JAK2 inhibitor	INHIBITOR	Other

Target Conservation


Protein: Tyrosine-protein kinase JAK2 Description: Tyrosine-protein kinase JAK2 Organism : Homo sapiens O60674 ENSG00000096968

Cross References

Resources	Reference
CAS NUMBER	1241914-87-3
ChEMBL	CHEMBL3545241
DrugBank	DB12535
FDA SRS	E7YVO9NSJ9
PubChem	46892373
SureChEMBL	SCHEMBL164912

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 27^th July 2026