RG3487

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Synonyms
Status
Molecule Category UNKNOWN

Structure

InChI Key CMRLNEYJEPELSM-BTQNPOSSSA-N
Smiles Cl.O=C(N[C@@H]1CN2CCC1CC2)c1n[nH]c2ccccc12
InChI
InChI=1S/C15H18N4O.ClH/c20-15(14-11-3-1-2-4-12(11)17-18-14)16-13-9-19-7-5-10(13)6-8-19;/h1-4,10,13H,5-9H2,(H,16,20)(H,17,18);1H/t13-;/m1./s1

Bioactivity

Mechanism of Action Action Reference
Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist PARTIAL AGONIST PubMed PubMed PubMed
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3E
Organism : Homo sapiens
A5X5Y0 ENSG00000186038
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3B
Organism : Homo sapiens
O95264 ENSG00000149305
Protein: Neuronal acetylcholine receptor protein alpha-7 subunit
Description: Neuronal acetylcholine receptor subunit alpha-7
Organism : Homo sapiens
P36544 ENSG00000175344
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3A
Organism : Homo sapiens
P46098 ENSG00000166736
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3D
Organism : Homo sapiens
Q70Z44 ENSG00000186090
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3C
Organism : Homo sapiens
Q8WXA8 ENSG00000178084
Assay Description Organism Bioactivity Reference
Antagonist activity at 5HT3 receptor expressed in N1E115 cells None 32.7 nM
Antagonist activity at 5HT3 receptor expressed in Xenopus oocyte None 2.8 nM
Agonist activity at human alpha7 nAChR expressed in Xenopus oocyte Homo sapiens 800.0 nM
Agonist activity at wild type monkey alpha7 nAChR by whole cell patch clamp assay Macaca mulatta 400.0 nM
Displacement of [3H]-MLA from alpha7 nAChR in rat brain membranes Rattus norvegicus 10.0 nM
Inhibition of 5HT3 receptor None 2.0 nM
Binding affinity to human alpha7 nAchR Homo sapiens 6.0 nM

Cross References

Resources Reference
ChEMBL CHEMBL3544952
CONTENTS