RG3487

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Synonyms
Status
Molecule Category Free-form
UNII O6J463N18M

Structure

InChI Key CMRLNEYJEPELSM-BTQNPOSSSA-N
Smiles Cl.O=C(N[C@@H]1CN2CCC1CC2)c1n[nH]c2ccccc12
InChI
InChI=1S/C15H18N4O.ClH/c20-15(14-11-3-1-2-4-12(11)17-18-14)16-13-9-19-7-5-10(13)6-8-19;/h1-4,10,13H,5-9H2,(H,16,20)(H,17,18);1H/t13-;/m1./s1

Pharmacology

Mechanism of Action Action Reference
Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist PARTIAL AGONIST PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- 2.8-32.7 - 2 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor alpha subunit
400-800 - - 6-10 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
800 - - 6 -
Macaca mulatta
400 - - - -
Rattus norvegicus
- - - 10 -

Target Conservation

Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3E
Organism : Homo sapiens
A5X5Y0 ENSG00000186038
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3B
Organism : Homo sapiens
O95264 ENSG00000149305
Protein: Neuronal acetylcholine receptor protein alpha-7 subunit
Description: Neuronal acetylcholine receptor subunit alpha-7
Organism : Homo sapiens
P36544 ENSG00000175344
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3A
Organism : Homo sapiens
P46098 ENSG00000166736
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3D
Organism : Homo sapiens
Q70Z44 ENSG00000186090
Protein: Serotonin 3 (5-HT3) receptor
Description: 5-hydroxytryptamine receptor 3C
Organism : Homo sapiens
Q8WXA8 ENSG00000178084

Cross References

Resources Reference
ChEMBL CHEMBL3544952
FDA SRS O6J463N18M
CONTENTS