EcoDrugPlus


Synonyms	BIIB-074 BIIB074 CNV-1014802 CNV1014802 GSK-1014802 GSK1014802 Raxatrigine Vixotrigine
Status
Molecule Category	Free-form
UNII	QQS4J85K6Y

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SubStructure

Threshold (%) >= 70


InChI Key	JESCETIFNOFKEU-SJORKVTESA-N
Smiles	NC(=O)[C@@H]1CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1
InChI	InChI=1S/C18H19FN2O2/c19-15-4-2-1-3-13(15)11-23-14-7-5-12(6-8-14)16-9-10-17(21-16)18(20)22/h1-8,16-17,21H,9-11H2,(H2,20,22)/t16-,17+/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H19FN2O2
Molecular Weight	314.36
AlogP	2.68
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	64.35
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	23.0

Mechanism of Action	Action	Reference
Sodium channel protein type IX alpha subunit blocker	BLOCKER	Other PubMed

Target Conservation


Protein: Sodium channel protein type IX alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432

Cross References

Resources	Reference
ChEMBL	CHEMBL3544913
DrugBank	DB11706
FDA SRS	QQS4J85K6Y
PubChem	16046068
SureChEMBL	SCHEMBL310473
ZINC	ZINC000034892269

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

VIXOTRIGINE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References