IMARADENANT

/static/temp/default.svg

Search structure


Synonyms	AZD-4635 AZD4635 Azd 4635 Azd4635 HTL-1071 HTL1071 Imaradenant
Status
Molecule Category	Free-form
UNII	770140J08A

Structure


InChI Key	NCWQLHHDGDXIJN-UHFFFAOYSA-N
Smiles	Cc1cc(-c2nnc(N)nc2-c2ccc(F)cc2)cc(Cl)n1
InChI	InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H11ClFN5
Molecular Weight	315.74
AlogP	3.28
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	77.58
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Adenosine A2a receptor antagonist	ANTAGONIST	Other PubMed

Target Conservation


Protein: Adenosine A2a receptor Description: Adenosine receptor A2a Organism : Homo sapiens P29274 ENSG00000128271

Cross References

Resources	Reference
ChEMBL	CHEMBL4594442
FDA SRS	770140J08A
Guide to Pharmacology	11153
PDB	F9Q
PubChem	86676119
SureChEMBL	SCHEMBL2320714

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025