TRICETAMIDE

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Search structure


Synonyms	R-548 Tricetamide
Status
Molecule Category	Free-form
UNII	V6X0RFU7AF
EPA CompTox	DTXSID10189835

Structure


InChI Key	NLRFFZRHTICQBO-UHFFFAOYSA-N
Smiles	CCN(CC)C(=O)CNC(=O)c1cc(OC)c(OC)c(OC)c1
InChI	InChI=1S/C16H24N2O5/c1-6-18(7-2)14(19)10-17-16(20)11-8-12(21-3)15(23-5)13(9-11)22-4/h8-9H,6-7,10H2,1-5H3,(H,17,20)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H24N2O5
Molecular Weight	324.38
AlogP	1.31
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	77.1
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Tyrosine-protein kinase JAK1 inhibitor	INHIBITOR	PubMed PubMed

Target Conservation


Protein: Tyrosine-protein kinase JAK1 Description: Tyrosine-protein kinase JAK1 Organism : Homo sapiens P23458 ENSG00000162434

Cross References

Resources	Reference
ChEMBL	CHEMBL2106468
FDA SRS	V6X0RFU7AF
PubChem	67763
SureChEMBL	SCHEMBL121292

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025