RIVENPROST

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Synonyms
Status
Molecule Category Free-form
UNII 1WBO45T413

Structure

InChI Key FBQUXLIJKPWCAO-AZIFJQEOSA-N
Smiles COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)OC)c1
InChI
InChI=1S/C24H34O6S/c1-29-16-18-6-3-5-17(13-18)14-19(25)8-9-20-21(23(27)15-22(20)26)10-12-31-11-4-7-24(28)30-2/h3,5-6,8-9,13,19-22,25-26H,4,7,10-12,14-16H2,1-2H3/b9-8+/t19-,20-,21-,22-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H34O6S
Molecular Weight 450.6
AlogP 2.94
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 13.0
Polar Surface Area 93.06
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 31.0

Pharmacology

Mechanism of Action Action Reference
Prostanoid EP4 receptor agonist AGONIST PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Prostanoid receptor
1.6 - - 56 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Mus musculus
1.6 - - 56 -

Target Conservation

Protein: Prostanoid EP4 receptor
Description: Prostaglandin E2 receptor EP4 subtype
Organism : Homo sapiens
P35408 ENSG00000171522

Cross References

Resources Reference
ChEBI 168543
ChEMBL CHEMBL303960
DrugBank DB16315
FDA SRS 1WBO45T413
Guide to Pharmacology 1930
PubChem 9803828
SureChEMBL SCHEMBL2309978
ZINC ZINC000003940680
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