GSK-2256098

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Search structure


Synonyms	Gsk-2256098 Gsk2256098
Status
Molecule Category	UNKNOWN
UNII	R7O0O4110G


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	BVAHPPKGOOJSPU-UHFFFAOYSA-N
Smiles	CONC(=O)c1ccccc1Nc1cc(Nc2cc(C)nn2C(C)C)ncc1Cl
InChI	InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)

Bioactivity

Mechanism of Action	Action	Reference
Focal adhesion kinase 1 inhibitor	INHIBITOR	PubMed DOI


Protein: Focal adhesion kinase 1 Description: Focal adhesion kinase 1 Organism : Homo sapiens Q05397 ENSG00000169398

Assay Description	Organism	Bioactivity	Reference
Inhibition of tracer 236 binding to recombinant human GST-tagged full length FAK expressed in baculovirus expression system incubated for 1 hr by Lanthascreen TR-FRET assay	Homo sapiens	0.67 nM
Inhibition of FAK (unknown origin)	Homo sapiens	0.8 nM
Inhibition of FAK in human U87MG cells assessed as reduction in phosphorylation at Y397 residue incubated for 30 mins by Western blot analysis	Homo sapiens	8.5 nM
Inhibition of FAK in human A549 cells assessed as reduction in phosphorylation at Y397 residue incubated for 30 mins by Western blot analysis	Homo sapiens	12.0 nM
Inhibition of FAK in human OVCAR8 cells assessed as reduction in phosphorylation at Y397 residue incubated for 30 mins by Western blot analysis	Homo sapiens	15.0 nM
Inhibition of FAK (unknown origin)	Homo sapiens	0.4 nM

Cross References

Resources	Reference
ChEMBL	CHEMBL3544967
FDA SRS	R7O0O4110G
PubChem	46214930

CONTENTS

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).