EcoDrugPlus


Synonyms	Amicos Clanzoflat Clanzol Clast Clebopride Clebopride hydrogen malate Clebopride malate Cleboril Cleprid LAS 9273 LAS-9273 Motilex
Status
Molecule Category	Free-form
ATC	A03FA06
UNII	I0A84520Y9
EPA CompTox	DTXSID7022831

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SubStructure

Threshold (%) >= 70


InChI Key	BVPWJMCABCPUQY-UHFFFAOYSA-N
Smiles	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1
InChI	InChI=1S/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C20H24ClN3O2
Molecular Weight	373.88
AlogP	3.33
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	67.59
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	26.0

Mechanism of Action	Action	Reference
Dopamine D2 receptor antagonist	ANTAGONIST	PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	890	-	-	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	602.56	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	-	-	600	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	17	-	1.13-170	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	-	-	89-104	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	104	-
Homo sapiens	-	602.56	-	-	-
Rattus norvegicus	-	-	-	1.13-11.9	-
Spodoptera frugiperda	-	-	-	10.4	-
Torpedo californica	-	890	-	-	-

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295












Protein: Serotonin 4 (5-HT4) receptor Description: 5-hydroxytryptamine receptor 4 Organism : Homo sapiens Q13639 ENSG00000164270

Cross References

Resources	Reference
ChEBI	92309
ChEMBL	CHEMBL325109
DrugBank	DB13511
DrugCentral	670
FDA SRS	I0A84520Y9
PubChem	2780
SureChEMBL	SCHEMBL25710
ZINC	ZINC000000608261

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

CLEBOPRIDE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References