EcoDrugPlus


Synonyms	BPN Bromfed Bromfenex Brompheniramine Brotane Dimetane Dimetapp Lodrane
Status
Molecule Category	Free-form
ATC	R06AB01
UNII	H57G17P2FN
EPA CompTox	DTXSID5022691


InChI Key	ZDIGNSYAACHWNL-UHFFFAOYSA-N
Smiles	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1
InChI	InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3

Property Name	Value
Molecular Formula	C16H19BrN2
Molecular Weight	319.25
AlogP	3.93
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	16.13
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	19.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	891.25	-	-	-
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	44-46
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	300	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	44-46
Homo sapiens	-	891.25	-	-	-

Resources	Reference
ChEBI	3183
ChEMBL	CHEMBL811
DrugBank	DB00835
DrugCentral	408
FDA SRS	H57G17P2FN
Human Metabolome Database	HMDB0001941
Guide to Pharmacology	7133
KEGG	C06857
PharmGKB	PA448675
PubChem	6834
SureChEMBL	SCHEMBL4814

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

BROMPHENIRAMINE

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Physicochemical Descriptors

Pharmacology

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