MINAPRINE


Synonyms	AGR-1240 Brantur CB-30038 Cantor Minaprine
Status
Molecule Category	UNKNOWN
ATC	N06AX07
UNII	00U7GX0NLM
EPA CompTox	DTXSID5048477


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	LDMWSLGGVTVJPG-UHFFFAOYSA-N
Smiles	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1
InChI	InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)

Mechanism of Action	Action	Reference
Acetylcholinesterase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed


Protein: Muscarinic acetylcholine receptor M1 Description: Muscarinic acetylcholine receptor M1 Organism : Homo sapiens P11229 ENSG00000168539










Protein: Monoamine oxidase A Description: Amine oxidase [flavin-containing] A Organism : Homo sapiens P21397 ENSG00000189221











Protein: Acetylcholinesterase Description: Acetylcholinesterase Organism : Homo sapiens P22303 ENSG00000087085











Protein: Serotonin 2 (5-HT2) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468












Protein: Serotonin 2 (5-HT2) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246











Protein: Serotonin 2 (5-HT2) receptor Description: 5-hydroxytryptamine receptor 2B Organism : Homo sapiens P41595 ENSG00000135914

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	85000	-	-	-
Enzyme Oxidoreductase	-	-	-	-	12-18
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor	-	17000	-	17000	-

Assay Description	Organism	Bioactivity
Percent Inhibition of trypanothione reductase activity at 28.5 uM concentration	Trypanosoma cruzi	16.0 %
Percent Inhibition of trypanothione reductase activity at 5.7 uM concentration	Trypanosoma cruzi	18.0 %
Percent Inhibition of trypanothione reductase activity at 57 uM concentration	Trypanosoma cruzi	12.0 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	17.29 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.03 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.03 %

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