MINAPRINE HYDROCHLORIDE

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Search structure


Synonyms	30038-CB 30038CB Cantor Minaprine dihydrochloride Minaprine hcl Minaprine hydrochloride NSC-305742
Status
Molecule Category	Salt-form
UNII	82Y7NT6DFT
EPA CompTox	DTXSID2045864

Structure


InChI Key	GNUCGROXDZMCJI-UHFFFAOYSA-N
Smiles	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1.Cl.Cl
InChI	InChI=1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H24Cl2N4O
Molecular Weight	371.31
AlogP	2.2
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	50.28
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Acetylcholinesterase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed

Target Conservation


Protein: Muscarinic acetylcholine receptor M1 Description: Muscarinic acetylcholine receptor M1 Organism : Homo sapiens P11229 ENSG00000168539










Protein: Monoamine oxidase A Description: Amine oxidase [flavin-containing] A Organism : Homo sapiens P21397 ENSG00000189221











Protein: Acetylcholinesterase Description: Acetylcholinesterase Organism : Homo sapiens P22303 ENSG00000087085












Protein: Serotonin 2 (5-HT2) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468













Protein: Serotonin 2 (5-HT2) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246












Protein: Serotonin 2 (5-HT2) receptor Description: 5-hydroxytryptamine receptor 2B Organism : Homo sapiens P41595 ENSG00000135914

Cross References

Resources	Reference
ChEBI	51040
ChEMBL	CHEMBL1364551
FDA SRS	82Y7NT6DFT
PubChem	33254
SureChEMBL	SCHEMBL124092

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025