TOLNAFTATE

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Search structure


Synonyms	Aftate Dr. scholl's athlete's foot spray Mycil NSC-233648 SCH 10144 SCH-10144 Separin Timoped Tinactin Tinaderm Tinaderm plus Tineafax Tolnaftate Tritin
Status
Molecule Category	Free-form
ATC	D01AE18
UNII	06KB629TKV
EPA CompTox	DTXSID3042477

Structure


InChI Key	FUSNMLFNXJSCDI-UHFFFAOYSA-N
Smiles	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1
InChI	InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H17NOS
Molecular Weight	307.42
AlogP	4.95
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	12.47
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	22.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	118.99-126.26

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	118.99-126.26

Cross References

Resources	Reference
ChEBI	9620
ChEMBL	CHEMBL83668
DrugBank	DB00525
DrugCentral	3617
FDA SRS	06KB629TKV
Human Metabolome Database	HMDB0005005
PharmGKB	PA164752438
PubChem	5510
SureChEMBL	SCHEMBL3520
ZINC	ZINC000000057522

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025