DASOLAMPANEL

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Synonyms
Status
Molecule Category Free-form
UNII 1P85D6BE9K

Structure

InChI Key LAKQPSQCICNZII-NOHGZBONSA-N
Smiles O=C(O)[C@@H]1C[C@H]2C[C@@H](Oc3cccc(Cl)c3-c3nnn[nH]3)CC[C@H]2CN1
InChI
InChI=1S/C17H20ClN5O3/c18-12-2-1-3-14(15(12)16-20-22-23-21-16)26-11-5-4-9-8-19-13(17(24)25)7-10(9)6-11/h1-3,9-11,13,19H,4-8H2,(H,24,25)(H,20,21,22,23)/t9-,10+,11-,13-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H20ClN5O3
Molecular Weight 377.83
AlogP 2.13
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 113.02
Molecular species ZWITTERION
Aromatic Rings 2.0
Heavy Atoms 26.0

Pharmacology

Mechanism of Action Action Reference
Glutamate receptor ionotropic AMPA antagonist ANTAGONIST PubMed PubMed PubMed

Target Conservation

Protein: Glutamate receptor ionotropic kainate 1
Description: Glutamate receptor ionotropic, kainate 1
Organism : Homo sapiens
P39086 ENSG00000171189
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 1
Organism : Homo sapiens
P42261 ENSG00000155511
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 2
Organism : Homo sapiens
P42262 ENSG00000120251
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 3
Organism : Homo sapiens
P42263 ENSG00000125675
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 4
Organism : Homo sapiens
P48058 ENSG00000152578

Cross References

Resources Reference
ChEMBL CHEMBL2103869
FDA SRS 1P85D6BE9K
PDB SXI
PubChem 51049972
SureChEMBL SCHEMBL13390253
ZINC ZINC000034339219
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