APAZONE

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Search structure


Synonyms	AHR-3018 Apazone Apazone dihydrate Azapropazone Azapropazone dihydrate Cinnopropazone MI-85 MI-85DI NSC-102824 Prolixan Rheumox Rheumox 600
Status
Molecule Category	Free-form
UNII	K2VOT966ZI
EPA CompTox	DTXSID6045408

Structure


InChI Key	MPHPHYZQRGLTBO-UHFFFAOYSA-N
Smiles	CCCC1C(=O)N2C(N(C)C)=Nc3ccc(C)cc3N2C1=O
InChI	InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H20N4O2
Molecular Weight	300.36
AlogP	2.06
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	2.0
Polar Surface Area	56.22
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed PubMed PubMed

Target Conservation


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Cross References

Resources	Reference
ChEBI	38010
ChEMBL	CHEMBL1565476
DrugCentral	266
FDA SRS	K2VOT966ZI
PharmGKB	PA166049192
PubChem	26098
SureChEMBL	SCHEMBL3190

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025