LOFEPRAMINE HYDROCHLORIDE


Synonyms	Amplit Feprapax Gamanil Lofepramine hcl Lofepramine hydrochloride Lomont WHR-2908A
Status
Molecule Category	Salt-form
UNII	Z24K96F991
EPA CompTox	DTXSID9047833

Structure


InChI Key	ZWZIQPOLMDPIQM-UHFFFAOYSA-N
Smiles	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1.Cl
InChI	InChI=1S/C26H27ClN2O.ClH/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29;/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C26H28Cl2N2O
Molecular Weight	455.43
AlogP	5.78
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	7.0
Polar Surface Area	23.55
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	30.0

Cross References

Resources	Reference
ChEBI	31780
ChEMBL	CHEMBL2106638
FDA SRS	Z24K96F991
PubChem	33611
SureChEMBL	SCHEMBL120115

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).