PHENYLPROPANOLAMINE HYDROCHLORIDE


Synonyms	Dexatrim Dimotapp Dimotapp l.a. Eskornade NSC-23798 Norephedrine hydrochloride Phenylpropanolamine chloride Phenylpropanolamine hcl Phenylpropanolamine hydrochloride Procol Propadrine hydrochloride Propagest Sine-off Triogesic Triominic
Status
Molecule Category	Salt-form
UNII	8D5I63UE1Q


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	DYWNLSQWJMTVGJ-UHFFFAOYSA-N
Smiles	CC(N)C(O)c1ccccc1.Cl
InChI	InChI=1S/C9H13NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7,9,11H,10H2,1H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C9H14ClNO
Molecular Weight	187.67
AlogP	1.07
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	46.25
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	11.0

Bioactivity

Mechanism of Action	Action	Reference
Alpha-1a adrenergic receptor agonist	AGONIST	PubMed Wikipedia Wikipedia Wikipedia Wikipedia


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Alpha-1a adrenergic receptor Description: Alpha-1A adrenergic receptor Organism : Homo sapiens P35348 ENSG00000120907

Cross References

Resources	Reference
ChEMBL	CHEMBL1200695
FDA SRS	8D5I63UE1Q
PubChem	62943
SureChEMBL	SCHEMBL4011782

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).