EcoDrugPlus


Synonyms	Mesulfa Methypyrimal NSC-27259 Sulfamerazine Sulfamerazine (trisulfapyrimidines) Sulfamethyldiazine Sulphamerazine Sumedin
Status
Molecule Category	Free-form
ATC	D06BA06 J01ED07
UNII	UR1SAB295F
EPA CompTox	DTXSID0023612


InChI Key	QPPBRPIAZZHUNT-UHFFFAOYSA-N
Smiles	Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1
InChI	InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

Property Name	Value
Molecular Formula	C11H12N4O2S
Molecular Weight	264.31
AlogP	1.17
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	97.97
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	18.0

Mechanism of Action	Action	Reference
Bacterial dihydropteroate synthase inhibitor	INHIBITOR	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	84.88-101.18

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	84.88-101.18
Plasmodium falciparum	-	6	-	-	-

Resources	Reference
CAS NUMBER	127-79-7
ChEBI	102130
ChEMBL	CHEMBL438
DrugBank	DB01581
DrugCentral	2510
FDA SRS	UR1SAB295F
Human Metabolome Database	HMDB0015521
PharmGKB	PA164776842
PubChem	5325
SureChEMBL	SCHEMBL33999
ZINC	ZINC000000057501

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 27^th July 2026

SULFAMERAZINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References