EcoDrugPlus


Synonyms	Abboflox BRL 2039 BRL-2039 Culpen Floxacillin Floxacillin sodium Floxacillin sodium anhydrous Floxapen Fluclomix-250 Fluclomix-500 Flucloxacillin Flucloxacillin sodium Flucloxacillin sodium anhydrous Flucloxin Galfloxin
Status
Molecule Category	Free-form
UNII	43B2M34G2V
EPA CompTox	DTXSID8023056


InChI Key	UIOFUWFRIANQPC-JKIFEVAISA-N
Smiles	Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O
InChI	InChI=1S/C19H17ClFN3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1

Property Name	Value
Molecular Formula	C19H17ClFN3O5S
Molecular Weight	453.88
AlogP	2.69
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	112.74
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	30.0

Mechanism of Action	Action	Reference
Bacterial penicillin-binding protein inhibitor	INHIBITOR	BNF

Resources	Reference
ChEBI	5098
ChEMBL	CHEMBL222645
DrugBank	DB00301
DrugCentral	1183
FDA SRS	43B2M34G2V
Human Metabolome Database	HMDB0014446
Guide to Pharmacology	10910
KEGG	C11748
PharmGKB	PA164781042
SureChEMBL	SCHEMBL3823
ZINC	ZINC000004102187

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

FLOXACILLIN

Structure

Physicochemical Descriptors

Pharmacology

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