MK-8777

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Search structure


Synonyms	Mk-8777 Org-26576
Status
Molecule Category	Free-form
UNII	0H1IDR8Z4F

Pharmacology

Mechanism of Action	Action	Reference
Glutamate receptor ionotropic AMPA positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	PubMed PubMed Wikipedia

Target Conservation


Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 1 Organism : Homo sapiens P42261 ENSG00000155511












Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 2 Organism : Homo sapiens P42262 ENSG00000120251











Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 3 Organism : Homo sapiens P42263 ENSG00000125675












Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 4 Organism : Homo sapiens P48058 ENSG00000152578

Cross References

Resources	Reference
ChEMBL	CHEMBL3707401
FDA SRS	0H1IDR8Z4F

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025