MK-8777

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Search structure


Synonyms	Mk-8777 Org-26576
Status
Molecule Category	UNKNOWN


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Bioactivity

Mechanism of Action	Action	Reference
Glutamate receptor ionotropic AMPA positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	PubMed PubMed Wikipedia


Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 1 Organism : Homo sapiens P42261 ENSG00000155511











Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 2 Organism : Homo sapiens P42262 ENSG00000120251











Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 3 Organism : Homo sapiens P42263 ENSG00000125675











Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 4 Organism : Homo sapiens P48058 ENSG00000152578

Cross References

Resources	Reference
ChEMBL	CHEMBL3707401

CONTENTS

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).