RAMOSETRON HYDROCHLORIDE

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Search structure


Synonyms	(r)-(-)-ramosetron hydrochloride Irribow Ramosetron hydrochloride YM-060 YM060 Ym060
Status
Molecule Category	Salt-form
UNII	9551LHD87E
EPA CompTox	DTXSID3021223

Structure


InChI Key	XIXYTCLDXQRHJO-RFVHGSKJSA-N
Smiles	Cl.Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21
InChI	InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H18ClN3O
Molecular Weight	315.8
AlogP	2.89
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	50.68
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	21.0

Pharmacology

Mechanism of Action	Action	Reference
Serotonin 3 (5-HT3) receptor antagonist	ANTAGONIST	Other

Target Conservation


Protein: Serotonin 3 (5-HT3) receptor Description: 5-hydroxytryptamine receptor 3E Organism : Homo sapiens A5X5Y0 ENSG00000186038





Protein: Serotonin 3 (5-HT3) receptor Description: 5-hydroxytryptamine receptor 3B Organism : Homo sapiens O95264 ENSG00000149305










Protein: Serotonin 3 (5-HT3) receptor Description: 5-hydroxytryptamine receptor 3A Organism : Homo sapiens P46098 ENSG00000166736












Protein: Serotonin 3 (5-HT3) receptor Description: 5-hydroxytryptamine receptor 3D Organism : Homo sapiens Q70Z44 ENSG00000186090






Protein: Serotonin 3 (5-HT3) receptor Description: 5-hydroxytryptamine receptor 3C Organism : Homo sapiens Q8WXA8 ENSG00000178084

Cross References

Resources	Reference
ChEBI	32088
ChEMBL	CHEMBL3181841
FDA SRS	9551LHD87E
PubChem	107999
SureChEMBL	SCHEMBL447023

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025