SARIZOTAN HYDROCHLORIDE

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Search structure


Synonyms	EMD 128130 EMD-128130 Emd128130 Sarizotan hcl Sarizotan hydrochloride
Status
Molecule Category	Salt-form
UNII	5P71E6YO9H
EPA CompTox	DTXSID60173163

Structure


InChI Key	QDLVYMYXOLGZOD-ZMBIFBSDSA-N
Smiles	Cl.Fc1ccc(-c2cncc(CNC[C@H]3CCc4ccccc4O3)c2)cc1
InChI	InChI=1S/C22H21FN2O.ClH/c23-20-8-5-17(6-9-20)19-11-16(12-24-14-19)13-25-15-21-10-7-18-3-1-2-4-22(18)26-21;/h1-6,8-9,11-12,14,21,25H,7,10,13,15H2;1H/t21-;/m1./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H22ClFN2O
Molecular Weight	384.88
AlogP	4.37
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	34.15
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	26.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine D2 receptor partial agonist	PARTIAL AGONIST	PubMed PubMed

Target Conservation


Protein: Serotonin 1a (5-HT1a) receptor Description: 5-hydroxytryptamine receptor 1A Organism : Homo sapiens P08908 ENSG00000178394











Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295












Protein: Dopamine D4 receptor Description: D(4) dopamine receptor Organism : Homo sapiens P21917 ENSG00000069696










Protein: Dopamine D3 receptor Description: D(3) dopamine receptor Organism : Homo sapiens P35462 ENSG00000151577

Cross References

Resources	Reference
ChEMBL	CHEMBL2146110
FDA SRS	5P71E6YO9H
PubChem	6918387
SureChEMBL	SCHEMBL1685487

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025