REMOXIPRIDE

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Synonyms
Status
Molecule Category Free-form
ATC N05AL04
UNII 0223RD59PE
EPA CompTox DTXSID6045668

Structure

InChI Key GUJRSXAPGDDABA-NSHDSACASA-N
Smiles CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC
InChI
InChI=1S/C16H23BrN2O3/c1-4-19-9-5-6-11(19)10-18-16(20)14-13(21-2)8-7-12(17)15(14)22-3/h7-8,11H,4-6,9-10H2,1-3H3,(H,18,20)/t11-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H23BrN2O3
Molecular Weight 371.28
AlogP 2.68
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 50.8
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 22.0

Pharmacology

Mechanism of Action Action Reference
Dopamine D2 receptor antagonist ANTAGONIST PubMed PubMed PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 1.202-880 - 873 62
Membrane receptor
- 1.202-880 - 55 62
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cavia porcellus
- - - 55 -
Homo sapiens
- - - -
monkey
- - - 873 -

Target Conservation

Protein: Dopamine D2 receptor
Description: D(2) dopamine receptor
Organism : Homo sapiens
P14416 ENSG00000149295

Related Entries

Cross References

Resources Reference
ChEBI 92948
ChEMBL CHEMBL22242
DrugBank DB00409
DrugCentral 2365
FDA SRS 0223RD59PE
Human Metabolome Database HMDB0014553
PharmGKB PA164749051
PubChem 54477
SureChEMBL SCHEMBL121339
ZINC ZINC000002021799
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