VABICASERIN HYDROCHLORIDE

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Search structure


Synonyms	SCA-136 Vabicaserin hydrochloride
Status
Molecule Category	Salt-form
UNII	2759C7222C

Structure


InChI Key	PYPPENBDXAWXJC-QNTKWALQSA-N
Smiles	Cl.c1cc2c3c(c1)[C@H]1CCC[C@H]1CN3CCNC2
InChI	InChI=1S/C15H20N2.ClH/c1-3-11-9-16-7-8-17-10-12-4-2-5-13(12)14(6-1)15(11)17;/h1,3,6,12-13,16H,2,4-5,7-10H2;1H/t12-,13-;/m0./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H21ClN2
Molecular Weight	264.8
AlogP	2.49
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Polar Surface Area	15.27
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	17.0

Pharmacology

Mechanism of Action	Action	Reference
Serotonin 2a (5-HT2a) receptor antagonist	ANTAGONIST	PubMed

Target Conservation


Protein: Serotonin 2a (5-HT2a) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468













Protein: Serotonin 2c (5-HT2c) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246












Protein: Serotonin 2b (5-HT2b) receptor Description: 5-hydroxytryptamine receptor 2B Organism : Homo sapiens P41595 ENSG00000135914

Cross References

Resources	Reference
ChEMBL	CHEMBL2104991
FDA SRS	2759C7222C
PubChem	11521821
SureChEMBL	SCHEMBL5477721

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025