LUMINESPIB


Synonyms	Luminespib NVP-AUY-922 NVP-AUY922 NVP-AUY922-NX VER-52296
Status
Molecule Category	Free-form
UNII	C6V1DAR5EB
EPA CompTox	DTXSID001336117


InChI Key	NDAZATDQFDPQBD-UHFFFAOYSA-N
Smiles	CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCOCC2)cc1
InChI	InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)

Mechanism of Action	Action	Reference
Heat shock protein HSP90 inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 1 Cytochrome P450 family 1A Cytochrome P450 1A2	-	-	-	-	23
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9	-	-	-	-	46
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6	-	-	-	-	30
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4	-	-	-	-	12
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	-	-	-	12.92
Other cytosolic protein	7	7-535	1.7	0.064-16	-
Other membrane protein	-	12-85	-	4	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Canis lupus familiaris	-	12	-	-	-
Homo sapiens	7	1-657	-	2-16	12-49.8
Human immunodeficiency virus 1	-	66.25	-	-	88.35


Protein: Heat shock protein HSP90 Description: Heat shock protein HSP 90-alpha Organism : Homo sapiens P07900 ENSG00000080824














Protein: Heat shock protein HSP90 Description: Heat shock protein HSP 90-beta Organism : Homo sapiens P08238 ENSG00000096384

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