EcoDrugPlus


Synonyms	NSC-47965 Pheniramine Propheniramine Prophenpyridamine Pyriton Tripoton
Status
Molecule Category	Free-form
ATC	D04AA16 R06AB05
UNII	134FM9ZZ6M
EPA CompTox	DTXSID0023454


InChI Key	IJHNSHDBIRRJRN-UHFFFAOYSA-N
Smiles	CN(C)CCC(c1ccccc1)c1ccccn1
InChI	InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3

Property Name	Value
Molecular Formula	C16H20N2
Molecular Weight	240.35
AlogP	3.17
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	16.13
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	18.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	24.9

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	24.9

Countries
Germany
Hungary
Romania
Serbia
Slovakia

Resources	Reference
ChEBI	91591
ChEMBL	CHEMBL1193
DrugBank	DB01620
DrugCentral	2132
FDA SRS	134FM9ZZ6M
Human Metabolome Database	HMDB0015557
Guide to Pharmacology	7267
PharmGKB	PA164744506
PubChem	4761
SureChEMBL	SCHEMBL4796

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

PHENIRAMINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Environmental Exposure

Cross References