EcoDrugPlus


Synonyms	Bleph-10 Bleph-30 Cetamide FML-S Klaron NSC-63871 Ocusulf-10 Ocusulf-30 SULF-10 SULF-15 Sulfacel-15 Sulfacetamide Sulfacetamide (triple sulfa) Sulfacetamidum Sulfair-15
Status
Molecule Category	Free-form
ATC	D10AF06 S01AB04
UNII	4965G3J0F5
EPA CompTox	DTXSID8026060


InChI Key	SKIVFJLNDNKQPD-UHFFFAOYSA-N
Smiles	CC(=O)NS(=O)(=O)c1ccc(N)cc1
InChI	InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

Property Name	Value
Molecular Formula	C8H10N2O3S
Molecular Weight	214.25
AlogP	0.09
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	89.26
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	14.0

Mechanism of Action	Action	Reference
Bacterial dihydropteroate synthase inhibitor	INHIBITOR	KEGG PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47 family of multidrug and toxin extrusion transporters	-	-	-	-	80

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	80

Resources	Reference
ChEBI	63845
ChEMBL	CHEMBL455
DrugBank	DB00634
DrugCentral	2497
FDA SRS	4965G3J0F5
Human Metabolome Database	HMDB0014772
PharmGKB	PA451536
PubChem	5320
SureChEMBL	SCHEMBL40863
ZINC	ZINC000005179119

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

SULFACETAMIDE

Structure

Physicochemical Descriptors

Pharmacology

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