NRX195183

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Search structure


Synonyms	AGN 195183 AGN-195183 IRX5183 Irx-5183 NRX-195183 Nrx195183 VTP-195183 VTP-5183
Status
Molecule Category	Free-form
UNII	RC87L028HU

Structure


InChI Key	PNAWUIKCVQSLFG-UHFFFAOYSA-N
Smiles	CC1(C)CCC(C)(C)c2c1cc(C(=O)Nc1cc(F)c(C(=O)O)c(F)c1)c(O)c2Cl
InChI	InChI=1S/C22H22ClF2NO4/c1-21(2)5-6-22(3,4)16-12(21)9-11(18(27)17(16)23)19(28)26-10-7-13(24)15(20(29)30)14(25)8-10/h7-9,27H,5-6H2,1-4H3,(H,26,28)(H,29,30)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H22ClF2NO4
Molecular Weight	437.87
AlogP	5.62
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	3.0
Polar Surface Area	86.63
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	30.0

Pharmacology

Mechanism of Action	Action	Reference
Retinoic acid receptor alpha agonist	AGONIST	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group B Nuclear hormone receptor subfamily 1 group B member 1	200	-	3	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	1.4-11	-	-	-

Target Conservation


Protein: Retinoic acid receptor alpha Description: Retinoic acid receptor alpha Organism : Homo sapiens P10276 ENSG00000131759

Cross References

Resources	Reference
ChEMBL	CHEMBL107430
DrugBank	DB05653
FDA SRS	RC87L028HU
SureChEMBL	SCHEMBL5531052
ZINC	ZINC000001909562

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025