CAPMATINIB HYDROCHLORIDE

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Synonyms
Status
Molecule Category Salt-form
UNII C2A374O70X

Structure

InChI Key COWBUPJEEDYWKD-UHFFFAOYSA-N
Smiles CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F.Cl.Cl.O
InChI
InChI=1S/C23H17FN6O.2ClH.H2O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;;;/h2-9,11-13H,10H2,1H3,(H,25,31);2*1H;1H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H21Cl2FN6O2
Molecular Weight 503.37
AlogP 3.43
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 85.07
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 31.0

Pharmacology

Mechanism of Action Action Reference
Hepatocyte growth factor receptor inhibitor INHIBITOR FDA

Target Conservation

Protein: Hepatocyte growth factor receptor
Description: Hepatocyte growth factor receptor
Organism : Homo sapiens
P08581 ENSG00000105976

Cross References

Resources Reference
ChEMBL CHEMBL3989937
FDA SRS C2A374O70X
PubChem 122201352
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