EcoDrugPlus


Synonyms	53858 Fenoprofen LILLY-53858 NSC-757813 Nalfon Progesic
Status
Molecule Category	Free-form
ATC	M01AE04
UNII	RA33EAC7KY
EPA CompTox	DTXSID9023045


InChI Key	RDJGLLICXDHJDY-UHFFFAOYSA-N
Smiles	CC(C(=O)O)c1cccc(Oc2ccccc2)c1
InChI	InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)

Property Name	Value
Molecular Formula	C15H14O3
Molecular Weight	242.27
AlogP	3.67
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	46.53
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	18.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	96.37-160.19

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	96.37-160.19
Homo sapiens	-	-	-	-

Resources	Reference
ChEBI	5004
ChEMBL	CHEMBL1297
DrugBank	DB00573
DrugCentral	1154
FDA SRS	RA33EAC7KY
Human Metabolome Database	HMDB0014713
Guide to Pharmacology	4820
KEGG	C06997
PharmGKB	PA449597
PubChem	3342
SureChEMBL	SCHEMBL3797

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

FENOPROFEN

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References