RG-1530

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Synonyms
Status
Molecule Category Free-form
UNII XQJ55R5PPQ

Structure

InChI Key UOVCGJXDGOGOCZ-UHFFFAOYSA-N
Smiles COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2
InChI
InChI=1S/C18H14ClFN4O/c1-9-16-18(24-23-9)21-14-8-15(25-2)13(20)7-11(14)17(22-16)10-5-3-4-6-12(10)19/h3-8H,1-2H3,(H2,21,23,24)

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H14ClFN4O
Molecular Weight 356.79
AlogP 4.75
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 62.3
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 25.0

Pharmacology

Mechanism of Action Action Reference
Fibroblast growth factor receptor 1 inhibitor INHIBITOR PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase RAD53 family
- 24 - - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family
- 58 - - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase PLK family
- - - 11 -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family
- 28 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 10 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 10-688 - 11 -

Target Conservation

Protein: Serine/threonine-protein kinase PLK4
Description: Serine/threonine-protein kinase PLK4
Organism : Homo sapiens
O00444 ENSG00000142731
Protein: Serine/threonine-protein kinase Aurora-A
Description: Aurora kinase A
Organism : Homo sapiens
O14965 ENSG00000087586
Protein: Platelet-derived growth factor receptor beta
Description: Platelet-derived growth factor receptor beta
Organism : Homo sapiens
P09619 ENSG00000113721
Protein: Fibroblast growth factor receptor 1
Description: Fibroblast growth factor receptor 1
Organism : Homo sapiens
P11362 ENSG00000077782
Protein: Vascular endothelial growth factor receptor
Description: Vascular endothelial growth factor receptor 1
Organism : Homo sapiens
P17948 ENSG00000102755
Protein: Fibroblast growth factor receptor 2
Description: Fibroblast growth factor receptor 2
Organism : Homo sapiens
P21802 ENSG00000066468
Protein: Vascular endothelial growth factor receptor
Description: Vascular endothelial growth factor receptor 3
Organism : Homo sapiens
P35916 ENSG00000037280
Protein: Vascular endothelial growth factor receptor
Description: Vascular endothelial growth factor receptor 2
Organism : Homo sapiens
P35968 ENSG00000128052
Protein: Tyrosine-protein kinase receptor FLT3
Description: Receptor-type tyrosine-protein kinase FLT3
Organism : Homo sapiens
P36888 ENSG00000122025

Cross References

Resources Reference
ChEMBL CHEMBL1980391
FDA SRS XQJ55R5PPQ
Guide to Pharmacology 10361
SureChEMBL SCHEMBL3824661
ZINC ZINC000035930738
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