GT-0918

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Search structure


Synonyms	Gt-0918 Proxalutamide Pruxelutamide
Status
Molecule Category	Free-form
UNII	QX6O64GP40

Structure


InChI Key	KCBJGVDOSBKVKP-UHFFFAOYSA-N
Smiles	CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2F)C(=S)N1c1ccc(CCCc2ncco2)nc1
InChI	InChI=1S/C24H19F4N5O2S/c1-23(2)21(34)32(17-9-6-14(12-29)19(20(17)25)24(26,27)28)22(36)33(23)16-8-7-15(31-13-16)4-3-5-18-30-10-11-35-18/h6-11,13H,3-5H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H19F4N5O2S
Molecular Weight	517.51
AlogP	5.19
Hydrogen Bond Acceptor	6.0
Number of Rotational Bond	6.0
Polar Surface Area	86.26
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	36.0

Pharmacology

Mechanism of Action	Action	Reference
Androgen Receptor antagonist	ANTAGONIST	PubMed Other

Target Conservation


Protein: Androgen Receptor Description: Androgen receptor Organism : Homo sapiens P10275 ENSG00000169083

Cross References

Resources	Reference
ChEMBL	CHEMBL4594417
FDA SRS	QX6O64GP40
PubChem	60194102
SureChEMBL	SCHEMBL12494226

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025