LIDOFLAZINE

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Synonyms
Status
Molecule Category Free-form
ATC C08EX01
UNII J4ZHN3HBTE
EPA CompTox DTXSID6045377

Structure

InChI Key ZBIAKUMOEKILTF-UHFFFAOYSA-N
Smiles Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChI
InChI=1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

Physicochemical Descriptors

Property Name Value
Molecular Formula C30H35F2N3O
Molecular Weight 491.63
AlogP 5.75
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 35.58
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 36.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 15.85-15.85 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - 77 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC28 and SLC29 families of nucleoside transporters SLC29 Facilitative nucleoside transporter family
- - - 279.9 90
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 15.85 - 279.9 90
Oryctolagus cuniculus
- - 31.62 - -
Rattus norvegicus
- - - 77 -

Cross References

Resources Reference
ChEBI 93095
ChEMBL CHEMBL92870
DrugBank DB13766
DrugCentral 1580
FDA SRS J4ZHN3HBTE
PharmGKB PA165818137
PubChem 3926
SureChEMBL SCHEMBL79037
ZINC ZINC000022034381
CONTENTS