PENTAERYTHRITOL TETRANITRATE


Synonyms	Cardiacap Mycardol Pentaerithritol tetranitrate Pentaerithrityl tetranitrate Pentaerythritol tetranitrate Pentaerythrityl tetranitrate Pentalong Pentanitrol Pentritol tempules Peritrate Peritrate sa
Status
Molecule Category	Free-form
UNII	10L39TRG1Z
EPA CompTox	DTXSID2023430

Structure


InChI Key	TZRXHJWUDPFEEY-UHFFFAOYSA-N
Smiles	O=[N+]([O-])OCC(CO[N+](=O)[O-])(CO[N+](=O)[O-])CO[N+](=O)[O-]
InChI	InChI=1S/C5H8N4O12/c10-6(11)18-1-5(2-19-7(12)13,3-20-8(14)15)4-21-9(16)17/h1-4H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C5H8N4O12
Molecular Weight	316.14
AlogP	-1.19
Hydrogen Bond Acceptor	12.0
Number of Rotational Bond	12.0
Polar Surface Area	209.48
Heavy Atoms	21.0

Pharmacology

Mechanism of Action	Action	Reference
Soluble guanylate cyclase activator	ACTIVATOR	Other PubMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Sus scrofa	7	-	-	-	-

Target Conservation


Protein: Soluble guanylate cyclase Description: Guanylate cyclase soluble subunit alpha-2 Organism : Homo sapiens P33402 ENSG00000152402












Protein: Soluble guanylate cyclase Description: Guanylate cyclase soluble subunit alpha-1 Organism : Homo sapiens Q02108 ENSG00000164116











Protein: Soluble guanylate cyclase Description: Guanylate cyclase soluble subunit beta-1 Organism : Homo sapiens Q02153 ENSG00000061918

Related Entries

Cross References

Resources	Reference
ChEBI	25879
ChEMBL	CHEMBL466659
DrugBank	DB06154
DrugCentral	2087
FDA SRS	10L39TRG1Z
PubChem	6518
SureChEMBL	SCHEMBL37177
ZINC	ZINC000008101167

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025