MOXISYLYTE


Synonyms	Acetoxythymoxamine Carlytene Erecnos Moxisylyte Moxisylyte hcl Moxisylyte hydrochloride Moxivig NSC-170448 Thymoxamine Thymoxamine hcl Thymoxamine hydrochloride
Status
Molecule Category	UNKNOWN
ATC	C04AX10 G04BE06
UNII	PW8QYA7KI0
EPA CompTox	DTXSID4023339


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	VRYMTAVOXVTQEF-UHFFFAOYSA-N
Smiles	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C
InChI	InChI=1S/C16H25NO3/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6/h9-11H,7-8H2,1-6H3

Mechanism of Action	Action	Reference
Adrenergic receptor alpha antagonist	ANTAGONIST	PubMed


Protein: Adrenergic receptor alpha Description: Alpha-2A adrenergic receptor Organism : Homo sapiens P08913 ENSG00000150594










Protein: Adrenergic receptor alpha Description: Alpha-2B adrenergic receptor Organism : Homo sapiens P18089 ENSG00000274286










Protein: Adrenergic receptor alpha Description: Alpha-2C adrenergic receptor Organism : Homo sapiens P18825 ENSG00000184160








Protein: Adrenergic receptor alpha Description: Alpha-1D adrenergic receptor Organism : Homo sapiens P25100 ENSG00000171873











Protein: Adrenergic receptor alpha Description: Alpha-1A adrenergic receptor Organism : Homo sapiens P35348 ENSG00000120907











Protein: Adrenergic receptor alpha Description: Alpha-1B adrenergic receptor Organism : Homo sapiens P35368 ENSG00000170214

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	-	31623	-	-

Assay Description	Organism	Bioactivity
In vitro relative blocking action (pA2) of the post-synaptic Alpha-1 adrenergic receptor from rat and rabbit aorta	Canis lupus familiaris	31.62 nM
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	15.02 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.17 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.17 %

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