NORNICOTINE

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
UNII 83H6L5QD8Z

Structure

InChI Key MYKUKUCHPMASKF-UHFFFAOYSA-N
Smiles c1cncc(C2CCCN2)c1
InChI
InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H12N2
Molecular Weight 148.21
AlogP 1.51
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 24.92
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 11.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor alpha subunit
- 80-300 1.06 29-730 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor beta subunit
- 80-300 - 29-30 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor delta subunit
- 100-300 - - -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor gamma subunit
- 100-300 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- - 1.06 - -
Mus musculus
- - 3.08 14 -
Rattus norvegicus
- 80-100 - 30 -
Torpedo
- 100-300 - - -

Cross References

Resources Reference
ChEMBL CHEMBL1132
FDA SRS 83H6L5QD8Z
Human Metabolome Database HMDB0001126
KEGG C06524
PubChem 91462
SureChEMBL SCHEMBL158145
CONTENTS