| Synonyms | |
| Status | |
| Molecule Category | Free-form |
| ATC | C05AD02 D04AB06 N01BA03 S01HA03 |
| UNII | 0619F35CGV |
| EPA CompTox | DTXSID1043883 |
Structure
| InChI Key | GKCBAIGFKIBETG-UHFFFAOYSA-N |
|---|---|
| Smiles | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C15H24N2O2 |
| Molecular Weight | 264.37 |
| AlogP | 2.62 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 8.0 |
| Polar Surface Area | 41.57 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 19.0 |
Pharmacology
| Mechanism of Action | Action | Reference |
|---|---|---|
| Sodium channel alpha subunit blocker | BLOCKER | ISBN PubMed PubMed PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | 56-740 | - | 500 | 72 |
Cavia porcellus
Homo sapiens
Target Conservation
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876 |
|
|||
|
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313 |
|
|||
Related Entries
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 9468 |
| ChEMBL | CHEMBL698 |
| DrugBank | DB09085 |
| DrugCentral | 2610 |
| FDA SRS | 0619F35CGV |
| KEGG | C07526 |
| PDB | TE4 |
| PubChem | 5411 |
| SureChEMBL | SCHEMBL34714 |
| ZINC | ZINC000001530811 |
CONTENTS
