EcoDrugPlus


Synonyms	DA-8159 Udenafil Zydena
Status
Molecule Category	Free-form
ATC	G04BE11
UNII	L5IB4XLY36

Datasets:

Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

Search:

Exact

Similarity

SubStructure

Threshold (%) >= 70


InChI Key	IYFNEFQTYQPVOC-UHFFFAOYSA-N
Smiles	CCCOc1ccc(S(=O)(=O)NCCC2CCCN2C)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1
InChI	InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H36N6O4S
Molecular Weight	516.67
AlogP	2.83
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	11.0
Polar Surface Area	122.21
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	36.0

Mechanism of Action	Action	Reference
Phosphodiesterase 5A inhibitor	INHIBITOR	PubMed

Target Conservation


Protein: Phosphodiesterase 5A Description: cGMP-specific 3',5'-cyclic phosphodiesterase Organism : Homo sapiens O76074 ENSG00000138735

Cross References

Resources	Reference
ChEBI	135926
ChEMBL	CHEMBL2103849
DrugBank	DB06267
DrugCentral	4141
FDA SRS	L5IB4XLY36
Human Metabolome Database	HMDB0015628
PharmGKB	PA164776753
PubChem	135413547
SureChEMBL	SCHEMBL120993

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

UDENAFIL

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References