|
In vitro inhibitory concentration required against human lung A549 carcinoma cells proliferation
|
Homo sapiens
|
18.0
nM
|
|
|
Inhibitory concentration against human T-cell leukemic cell line (CRFF-CEM) in vitro
|
Homo sapiens
|
0.025
ug.mL-1
|
|
|
Inhibition against CRFF-CEM-T-Cell leukemic cell line
|
Homo sapiens
|
0.025
ug.mL-1
|
|
|
In vitro cytotoxic activity against prostate carcinoma (DU-145) cells assayed by inhibition of [3H]-labeled thymidine incorporation
|
Homo sapiens
|
1.12
nM
|
|
|
Inhibitory activity against growth of HT-29 cell line
|
Homo sapiens
|
2.06
nM
|
|
|
Tested for cytotoxicity against HT-29 (MDR)cells
|
Homo sapiens
|
17.0
nM
|
|
|
Tested for cytotoxicity against HT-29 (wt)cells
|
Homo sapiens
|
1.0
nM
|
|
|
In vitro cytotoxic activity against colon adenocarcinoma (HT-29) cells assayed by inhibition of [3H]-labeled thymidine incorporation
|
Homo sapiens
|
0.01
nM
|
|
|
Cytotoxicity tested against Hela C1 cells
|
Homo sapiens
|
0.014
ug.mL-1
|
|
|
Cytotoxicity tested against Hela T5 cells
|
Homo sapiens
|
0.051
ug.mL-1
|
|
|
The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells
|
Mus musculus
|
3.4
nM
|
|
|
Compound was evaluated for its cytotoxicity against vincristine-sensitive KB/S human oral epidermoid carcinoma cell lines.
|
Homo sapiens
|
0.014
ug.mL-1
|
|
|
Compound was evaluated for its cytotoxicity against vincristine-resistant KB/VJ300 human oral epidermoid carcinoma cell lines.
|
Homo sapiens
|
1.05
ug.mL-1
|
|
|
Antiproliferative activity against drug-resistant tumor cell line KB7D.
|
Homo sapiens
|
35.0
nM
|
|
|
Concentration required to reduce proliferation of KB subclones passaged in the presence of etoposide 7 uM (KB7D) cell line by 50% as determined by the MTT method
|
Homo sapiens
|
50.0
nM
|
|
|
Concentration required to reduce proliferation of KB subclones passaged in the presence of vincristine 0.02 uM (KB7D) cell line by 50% as determined by the MTT method
|
Homo sapiens
|
200.0
nM
|
|
|
Antiproliferative activity against drug-resistant tumor cell line KBCamp.
|
Homo sapiens
|
5.0
nM
|
|
|
Antiproliferative activity against drug-resistant tumor cell line KBMDR.
|
Homo sapiens
|
350.0
nM
|
|
|
Antiproliferative activity against drug-resistant tumor cell line KBV20C.
|
Homo sapiens
|
50.0
nM
|
|
|
Concentration required to reduce proliferation of KB human nasopharyngeal carcinoma (KBWT) cell line by 50% as determined by the MTT method
|
Homo sapiens
|
4.0
nM
|
|
|
Antiproliferative activity against drug-resistant tumor cell line KBwt.
|
Homo sapiens
|
1.0
nM
|
|
|
Compound concentration required to reduce the cell proliferation of Wild type and Drug- resistant KB subclones passaged in the presence of doxorubicin 0.09 uM by 50%
|
Homo sapiens
|
700.0
nM
|
|
|
Compound concentration required to reduce the cell proliferation of Wild type and Drug- resistant human nasopharyngeal carcinoma KB cells by 50%
|
Homo sapiens
|
6.0
nM
|
|
|
Compound concentration required to reduce the cell proliferation of Wild type and drug-resistant KB subclones passaged in the presence of etoposide 7 uM by 50%
|
Homo sapiens
|
50.0
nM
|
|
|
Effect on the proliferation Wild -type and Drug- resistant KB subclones passaged in the presence of vincristine 0.02 uM
|
Homo sapiens
|
200.0
nM
|
|
|
Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours
|
Mus musculus
|
3.4
nM
|
|
|
Concentration that inhibits proliferation of cultured lymphoid leukemia L1210 cells to 50% control growth during 48 h
|
Mus musculus
|
3.4
nM
|
|
|
Tested for the inhibition of L1210 cell proliferation.
|
Mus musculus
|
4.85
nM
|
|
|
Inhibitory activity against growth of L1210 cell line
|
Mus musculus
|
0.73
nM
|
|
|
Inhibitory activity against growth of MCF-7 cell line
|
Homo sapiens
|
0.84
nM
|
|
|
In vitro cytotoxic activity against uterine sarcoma (MES-SA) cells assayed by inhibition of [3H]-labeled thymidine incorporation
|
Homo sapiens
|
0.02
nM
|
|
|
In vitro cytotoxic activity against nonsmall cell lung carcinoma (NCI-H460) cells assayed by inhibition of [3H]-labeled thymidine incorporation
|
Homo sapiens
|
0.13
nM
|
|
|
The compound was evaluated in vitro for the P388 cell spindle disruption.; 0.02-0.04
|
Mus musculus
|
20.0
nM
|
|
|
In vitro inhibitory concentration required against murine P388 leukemic cells proliferation
|
Mus musculus
|
2.0
nM
|
|
|
The compound tested for the inhibition of tubulin polymerization.
|
None
|
500.0
nM
|
|
|
The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay.
|
None
|
220.0
nM
|
|
|
The compound was evaluated in vitro for the inhibition of P388D1 cell colony formation.
|
Mus musculus
|
190.0
nM
|
|
|
The compound was evaluated in vitro for the inhibition of murine leukemia P388D1 cell proliferation.
|
Mus musculus
|
4.7
nM
|
|
|
Compound was tested for inhibition of tubulin polymerisation at 1 uM
|
None
|
83.0
%
|
|
|
Cytotoxicity against human HeLa cells by MTT assay
|
Homo sapiens
|
5.0
nM
|
|
|
Cytotoxicity against human HepG2 cells by MTT assay
|
Homo sapiens
|
200.0
nM
|
|
|
Cytotoxicity against human H295R cells by MTT assay
|
Homo sapiens
|
90.0
nM
|
|
|
Cytotoxicity against human Ovcar3 cells by MTT assay
|
Homo sapiens
|
20.0
nM
|
|
|
Cytotoxicity against human MCF7 cells by MTT assay
|
Homo sapiens
|
20.0
nM
|
|
|
Cytotoxicity against human Aro cells by MTT assay
|
Homo sapiens
|
0.1
nM
|
|
|
Cytotoxicity against human A549 cells by MTT assay
|
Homo sapiens
|
30.0
nM
|
|
|
Cytotoxicity against human HT29 cells by MTT assay
|
Homo sapiens
|
10.0
nM
|
|
|
Cytotoxicity against human PT45 cells by MTT assay
|
Homo sapiens
|
4.0
nM
|
|
|
Cytotoxicity against mouse 4T1 cells by MTT assay
|
Mus musculus
|
20.0
nM
|
|
|
Cytotoxicity against mouse BNL cells by MTT assay
|
Mus musculus
|
80.0
nM
|
|
|
Cytotoxicity against human MCF7 cells by MTT assay
|
Homo sapiens
|
0.05
ug.mL-1
|
|
|
Cytotoxicity against human MCF7 cells by clonogenic assay
|
Homo sapiens
|
0.15
ug.mL-1
|
|
|
Cytotoxicity against human WRL68 cells by MTT assay
|
Homo sapiens
|
1.42
ug.mL-1
|
|
|
Cytotoxicity against human WRL68 cells by clonogenic assay
|
Homo sapiens
|
8.5
ug.mL-1
|
|
|
Cytotoxicity against human KB cells by MTT assay
|
Homo sapiens
|
0.02
ug.mL-1
|
|
|
Cytotoxicity against human KB cells by clonogenic assay
|
Homo sapiens
|
0.25
ug.mL-1
|
|
|
Cytotoxicity against human PA1 cells by MTT assay
|
Homo sapiens
|
0.01
ug.mL-1
|
|
|
Cytotoxicity against human PA1 cells by clonogenic assay
|
Homo sapiens
|
1.0
ug.mL-1
|
|
|
Cytotoxicity against human Colo320DM cells by MTT assay
|
Homo sapiens
|
0.46
ug.mL-1
|
|
|
Cytotoxicity against human Colo320DM cells by clonogenic assay
|
Homo sapiens
|
1.5
ug.mL-1
|
|
|
Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA
|
Homo sapiens
|
26.0
nM
|
|
|
Antiproliferative activity against MDA435/LCC6 cells by ELISA
|
Homo sapiens
|
0.29
nM
|
|
|
Antiproliferative activity against adriamycin resistant P388 cells by ELISA
|
Mus musculus
|
299.0
nM
|
|
|
Antiproliferative activity against P388 cells by ELISA
|
Mus musculus
|
2.2
nM
|
|
|
Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
|
Homo sapiens
|
0.63
nM
|
|
|
Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
|
Mus musculus
|
4.5
nM
|
|
|
Cell cycle arrest in KB/HeLa cells by accumulation at G2/M phase
|
Homo sapiens
|
2.4
nM
|
|
|
Cytotoxicity against COLO205 cells
|
Homo sapiens
|
2.6
nM
|
|
|
Antiproliferative activity against KB cells expressing MDR1
|
Homo sapiens
|
2.2
nM
|
|
|
Antiproliferative activity against KB8.5 cells expressing MDR1
|
Homo sapiens
|
58.0
nM
|
|
|
Antiproliferative activity against human MDA-MB-231 cells after 4 days
|
Homo sapiens
|
4.5
nM
|
|
|
Cytotoxicity against COLO205 cells
|
Homo sapiens
|
2.6
nM
|
|
|
Antiproliferative activity against KB cells
|
Homo sapiens
|
2.2
nM
|
|
|
Antiproliferative activity against KB8.5 cells
|
Homo sapiens
|
58.0
nM
|
|
|
Growth inhibition of Pgp deficient MCF7 cells expressing MRP1
|
Homo sapiens
|
0.6
nM
|
|
|
Growth inhibition of NCI/ADR cells expressing Pgp/MRP1
|
Homo sapiens
|
100.0
nM
|
|
|
Growth inhibition of Pgp deficient MCF7/VP cells expressing MRP1
|
Homo sapiens
|
9.3
nM
|
|
|
Cytotoxicity against human A549 cells by SRB microtiter plate assay
|
Homo sapiens
|
40.0
nM
|
|
|
Cytotoxicity against human KB cells by SRB microtiter plate assay
|
Homo sapiens
|
6.0
nM
|
|
|
Cytotoxicity against human DU145 cells by SRB microtiter plate assay
|
Homo sapiens
|
8.5
nM
|
|
|
Cytotoxicity against human ZR751cells by SRB microtiter plate assay
|
Homo sapiens
|
40.0
nM
|
|
|
Cytotoxicity against A549 cells after 48 hrs by MTT assay
|
Homo sapiens
|
360.0
nM
|
|
|
Cytotoxicity against SMMC7721 cells after 48 hrs by MTT assay
|
Homo sapiens
|
120.0
nM
|
|
|
Cytotoxicity against AGS cells after 48 hrs by MTT assay
|
Homo sapiens
|
120.0
nM
|
|
|
Cytotoxicity against HT29 cells after 48 hrs by MTT assay
|
Homo sapiens
|
210.0
nM
|
|
|
Inhibition of tubulin polymerization at 20 uM
|
Homo sapiens
|
87.0
%
|
|
|
Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by MTT assay
|
Homo sapiens
|
6.0
nM
|
|
|
Cytotoxicity against human multidrug resistant Lucena1 cells assessed as cell viability after 48 hrs by MTT assay
|
Homo sapiens
|
100.0
nM
|
|
|
Antiproliferative activity against human MDA-MB-231 cells after 4 days by microplate assay
|
Homo sapiens
|
4.5
nM
|
|
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
Homo sapiens
|
5.0
nM
|
|
|
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
|
Homo sapiens
|
200.0
nM
|
|
|
Cytotoxicity against human H295R cells after 72 hrs by MTT assay
|
Homo sapiens
|
90.0
nM
|
|
|
Cytotoxicity against human Ovcar3 cells after 72 hrs by MTT assay
|
Homo sapiens
|
20.0
nM
|
|
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
Homo sapiens
|
20.0
nM
|
|
|
Cytotoxicity against human Aro cells after 72 hrs by MTT assay
|
Homo sapiens
|
0.3
nM
|
|
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
Homo sapiens
|
30.0
nM
|
|
|
Cytotoxicity against human HT29 cells after 72 hrs by MTT assay
|
Homo sapiens
|
10.0
nM
|
|
|
Cytotoxicity against human PT45 cells after 72 hrs by MTT assay
|
Homo sapiens
|
4.0
nM
|
|
|
Cytotoxicity against human OE19 cells after 72 hrs by MTT assay
|
Homo sapiens
|
50.0
nM
|
|
|
Cytotoxicity against human OE33 cells after 72 hrs by MTT assay
|
Homo sapiens
|
30.0
nM
|
|
|
Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis
|
Homo sapiens
|
2.4
nM
|
|
|
Cytotoxicity againt multidrug-resistant human 2780AD cells
|
Homo sapiens
|
895.0
nM
|
|
|
Cytotoxicity againt human A2780 cells
|
Homo sapiens
|
0.9
nM
|
|
|
Growth inhibition of human A2780 cells
|
Homo sapiens
|
3.1
nM
|
|
|
Growth inhibition of multidrug-resistant human 2780AD cells
|
Homo sapiens
|
311.0
nM
|
|
|
Cytotoxicity against human KB cells
|
Homo sapiens
|
16.7
nM
|
|
|
Cytotoxicity against human KB cells
|
Homo sapiens
|
2.8
nM
|
|
|
Cytotoxicity against human A172 cells after 6 days
|
Homo sapiens
|
0.0007
ug.mL-1
|
|
|
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
|
Homo sapiens
|
43.0
nM
|
|
|
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
|
Homo sapiens
|
58.0
nM
|
|
|
Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
|
Homo sapiens
|
12.0
nM
|
|
|
Cytotoxicity against human KB cells assessed as cell viability after 48 hrs by MTS assay
|
Homo sapiens
|
7.9
nM
|
|
|
Cytotoxicity against human BGC823 cells
|
Homo sapiens
|
0.066
ug.mL-1
|
|
|
Cytotoxicity against human CCRF-CEM cells
|
Homo sapiens
|
0.06
ug.mL-1
|
|
|
Cell cycle arrest in human KB/HeLa cells assessed as G2/M phase accumulation after 24 hrs by FACS analysis
|
Homo sapiens
|
2.4
nM
|
|
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay
|
Homo sapiens
|
15.0
nM
|
|
|
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay
|
Homo sapiens
|
15.0
nM
|
|
|
Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay
|
Homo sapiens
|
10.0
nM
|
|
|
Cytotoxicity against human UCI101 cells after 48 hrs by alamar blue assay
|
Homo sapiens
|
20.0
nM
|
|
|
Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
|
Homo sapiens
|
7.0
nM
|
|
|
Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
|
Mus musculus
|
1.2
nM
|
|
|
Cytotoxicity against human SMMC7721 cells by MTT assay
|
Homo sapiens
|
20.74
ug.mL-1
|
|
|
Cytotoxicity against human HO8910 cells by MTT assay
|
Homo sapiens
|
1.37
ug.mL-1
|
|
|
Cytotoxicity against human MRP1 expressing hamster BHK21 cells after 72 hrs by MTT assay
|
Mesocricetus auratus
|
9.42
nM
|
|
|
Cytotoxicity against hamster BHK21 cells after 72 hrs by MTT assay
|
Mesocricetus auratus
|
1.51
nM
|
|
|
Cytotoxicity against vincristine sensitive human KB/S cells
|
Homo sapiens
|
5.4
nM
|
|
|
Inhibition of Agrobacterium tumefaciens-induced tumor growth in potato tuber disk after 21 days
|
Agrobacterium tumefaciens
|
0.003
ppm
|
|
|
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
|
Homo sapiens
|
40.0
nM
|
|
|
Inhibition of HIV1 RT
|
Human immunodeficiency virus 1
|
200.0
ug.mL-1
|
|
|
Antitumor activity against Agrobacterium tumefaciens B6-induced tumor formation at 10 ug/disk after 12 days by potato disk assay
|
Agrobacterium tumefaciens
|
-44.0
%
|
|
|
Antitumor activity against Agrobacterium tumefaciens B6-induced tumor formation at 5 ug/disk after 12 days by potato disk assay
|
Agrobacterium tumefaciens
|
-36.0
%
|
|
|
Antitumor activity against Agrobacterium tumefaciens B6-induced tumor formation at 2.5 ug/disk after 12 days by potato disk assay
|
Agrobacterium tumefaciens
|
-17.0
%
|
|
|
Antiproliferative activity against human MDA-MB-231 cells after 4 days by microplate assay
|
Homo sapiens
|
6.0
nM
|
|
|
Antiproliferative activity against human MCF7 cells after 5 days by microplate assay
|
Homo sapiens
|
2.0
nM
|
|
|
Growth inhibition of human Jurkat cells
|
Homo sapiens
|
0.0031
ug.mL-1
|
|
|
Antiproliferative activity against human COLO205 cells after 24 hrs by MTS assay
|
Homo sapiens
|
2.6
nM
|
|
|
Antiproliferative activity against human KB cells after 3 days by SRB assay
|
Homo sapiens
|
2.2
nM
|
|
|
Antiproliferative activity against human KB 8.5 cells after 3 days by SRB assay
|
Homo sapiens
|
58.0
nM
|
|
|
Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
|
Homo sapiens
|
0.4
nM
|
|
|
Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay
|
Homo sapiens
|
90.1
nM
|
|
|
Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-TAX50 cells after 72 hrs by methylene blue dye assay
|
Homo sapiens
|
17.6
nM
|
|
|
Growth inhibition of human KB-7D cells overexpressing multidrug resistant associated protein after 72 hrs by methylene blue dye assay
|
Homo sapiens
|
1.2
nM
|
|
|
Cytotoxicity against human NCI-H292 cells after 72 hrs by MTT assay
|
Homo sapiens
|
0.04
ug.mL-1
|
|
|
Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay
|
Homo sapiens
|
0.003
ug.mL-1
|
|
|
Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay
|
Homo sapiens
|
597.2
nM
|
|
|
Cytotoxicity against human CCRF-CEM/C2 cells after 48 hrs by cell titer-blue assay
|
Homo sapiens
|
366.6
nM
|
|
|
Cytotoxicity against human HL60/MX2 cells after 48 hrs by cell titer-blue assay
|
Homo sapiens
|
60.88
nM
|
|
|
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
|
Homo sapiens
|
0.87
nM
|
|
|
Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay
|
Homo sapiens
|
10.0
nM
|
|
|
Antiproliferative activity against human KB/VCR cells after 72 hrs by sulforhodamine B assay
|
Homo sapiens
|
840.0
nM
|
|
|
Cell cycle arrest in human KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
|
Homo sapiens
|
2.4
nM
|
|
|
Cytotoxicity against human KB cells after 48 hrs by MTT assay
|
Homo sapiens
|
6.07
nM
|
|
|
Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay
|
Chlorocebus sabaeus
|
1.1
ug.mL-1
|
|
|
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
Homo sapiens
|
0.05
ug.mL-1
|
|
|
Antiproliferative activity against mouse neural precursor cells by MTT assay
|
Mus musculus
|
1.0
nM
|
|
|
Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay
|
Plasmodium falciparum
|
1.0
nM
|
|
|
Cytotoxicity in vincristine-resistant human KB/VJ300 cells in presence of 0.1 ug/ml vincristine
|
Homo sapiens
|
25.0
ug.mL-1
|
|
|
Cytotoxicity against vincristine-sensitive human KB cells in presence of 0.1 ug/ml vincristine
|
Homo sapiens
|
25.0
ug.mL-1
|
|
|
Cytotoxic activity against Pgp-deficient human MCF7/VP cells expressing MRP1 after 48 hrs by sulforhodamine B assay
|
Homo sapiens
|
9.3
nM
|
|
|
Cytotoxic activity against drug-sensitive Pgp-, MRP1-deficient human MCF7 cells after 48 hrs by sulforhodamine B assay in presence of 50 nM vinblastin
|
Homo sapiens
|
0.6
nM
|
|
|
Cell cycle arrest in human KB/HeLa cells assessed as accumulation of cells at G2/M phase after 24 hrs by flow cytometry
|
Homo sapiens
|
2.4
nM
|
|
|
Cytotoxicity against human KB cells after 72 hrs by SRB assay
|
Homo sapiens
|
20.0
nM
|
|
|
Antiproliferative activity against MDR-1 overexpressing human 786-0 cells
|
Homo sapiens
|
37.0
nM
|
|
|
Antiproliferative activity against MDR-1 overexpressing human 786-0 cells in presence of MDR1 inhibitor verapamil
|
Homo sapiens
|
1.2
nM
|
|
|
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay
|
Homo sapiens
|
3.0
nM
|
|
|
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
|
Homo sapiens
|
2.0
nM
|
|
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
|
Homo sapiens
|
6.0
nM
|
|
|
Growth inhibition of human KB cells after 72 hrs by methylene blue assay
|
Homo sapiens
|
0.4
nM
|
|
|
Growth inhibition of human KB-VIN10 cells after 72 hrs by methylene blue assay
|
Homo sapiens
|
90.1
nM
|
|
|
Growth inhibition of human KB-7d cells after 72 hrs by methylene blue assay
|
Homo sapiens
|
1.2
nM
|
|
|
Growth inhibition of human KB-S15 cells after 72 hrs by methylene blue assay
|
Homo sapiens
|
17.6
nM
|
|
|
Antiproliferative activity against human SNU398 cells
|
Homo sapiens
|
46.7
nM
|
|
|
Antiproliferative activity against human PLC/PRF/5 cells
|
Homo sapiens
|
12.7
nM
|
|
|
Antiproliferative activity against human SMMC7721 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
6.5
nM
|
|
|
Antiproliferative activity against human MHCC97H after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
21.2
nM
|
|
|
Antiproliferative activity against human Bel7402 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
4.2
nM
|
|
|
Antiproliferative activity against human Hep3B after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
100.0
nM
|
|
|
Antiproliferative activity against human HepG2 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
100.0
nM
|
|
|
Antiproliferative activity against human HuH7 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
20.0
nM
|
|
|
Antiproliferative activity against human JHH2 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
100.0
nM
|
|
|
Antiproliferative activity against human JHH4 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
7.2
nM
|
|
|
Antiproliferative activity against human JHH7 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
28.2
nM
|
|
|
Antiproliferative activity against human PLC/PRF/5 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
22.1
nM
|
|
|
Antiproliferative activity against human SNU182 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
35.9
nM
|
|
|
Antiproliferative activity against human SNU387 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
40.9
nM
|
|
|
Antiproliferative activity against human SNU398 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
0.13
nM
|
|
|
Antiproliferative activity against human SNU423 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
18.4
nM
|
|
|
Antiproliferative activity against human SNU449 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
100.0
nM
|
|
|
Antiproliferative activity against human SNU475 after 72 hrs by CellTiter Glo assay
|
Homo sapiens
|
29.3
nM
|
|
|
Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
|
Homo sapiens
|
60.0
nM
|
|
|
Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
|
Homo sapiens
|
0.1
nM
|
|
|
Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
|
Homo sapiens
|
0.17
nM
|
|
|
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting
|
Homo sapiens
|
3.9
%
|
|
|
Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting
|
Homo sapiens
|
59.8
%
|
|
|
Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting
|
Homo sapiens
|
13.0
%
|
|
|
Cytotoxicity against human HCT116 cells
|
Homo sapiens
|
7.0
nM
|
|
|
Cytotoxicity against mouse L1210 cells
|
Mus musculus
|
6.0
nM
|
|
|
Cytotoxicity against human KB-VIN10 cells after 72 hrs by SRB assay
|
Homo sapiens
|
303.2
nM
|
|
|
Cytotoxicity against human KB cells after 72 hrs by SRB assay
|
Homo sapiens
|
2.11
nM
|
|
|
Antiproliferative activity against temperature-sensitive rat lymphatic endothelial cells after 48 hrs by MTS assay
|
Rattus norvegicus
|
80.0
nM
|
|
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTS assay
|
Homo sapiens
|
4.3
nM
|
|
|
Cytotoxicity against taxol-resistant human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
75.0
nM
|
|
|
Cytotoxicity against human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
12.0
nM
|
|
|
Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
139.0
nM
|
|
|
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
500.0
nM
|
|
|
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
12.0
nM
|
|
|
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
210.0
nM
|
|
|
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
53.0
nM
|
|
|
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
|
Homo sapiens
|
13.0
nM
|
|
|
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei 427 after 3 days by Alamar Blue assay
|
Trypanosoma brucei brucei
|
30.0
nM
|
|
|
Cytotoxicity against human KB-7d cells overexpressing MRP assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
|
Homo sapiens
|
1.2
nM
|
|
|
Cytotoxicity against human KB-S15 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
|
Homo sapiens
|
17.6
nM
|
|
|
Cytotoxicity against human KB-VIN10 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
|
Homo sapiens
|
90.1
nM
|
|
|
Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
|
Homo sapiens
|
0.6
nM
|
|
|
Inhibition of tubulin polymerization (unknown origin) at 20 uM by spectrophotometric analysis
|
Homo sapiens
|
77.0
%
|
|
|
Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
|
Homo sapiens
|
15.0
nM
|
|
|
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTitre-Blue assay
|
Homo sapiens
|
1.6
nM
|
|
|
Competitive inhibition of dog brain tubulin using BODIPY FL-vinblastine as substrate at 10 uM incubated for 30 mins prior to substrate addition measured after 30 mins by fluorescence assay
|
Canis lupus familiaris
|
50.0
%
|
|
|
Cytotoxicity against human KB cells after 72 hrs by methylene blue assay
|
Homo sapiens
|
0.9
nM
|
|
|
Cytotoxicity against human vincristine/paclitaxel-resistant KB-VIN10 cells overexpressing P-gp170 after 72 hrs by methylene blue assay
|
Homo sapiens
|
96.4
nM
|
|
|
Cytotoxicity against human vincristine/paclitaxel-resistant KB-S15 cells overexpressing P-gp170 after 72 hrs by methylene blue assay
|
Homo sapiens
|
2.1
nM
|
|
|
Cytotoxicity against human VP16-resistant KB-7d cells overexpressing MRP after 72 hrs by methylene blue assay
|
Homo sapiens
|
1.5
nM
|
|
|
Cytotoxicity against vincristine-sensitive human KB cells
|
Homo sapiens
|
0.007
ug.mL-1
|
|
|
Cytotoxicity against vincristine-resistant human KB/VJ300 cells
|
Homo sapiens
|
5.4
ug.mL-1
|
|
|
Antiproliferative activity against human KB cells
|
Homo sapiens
|
0.4
nM
|
|
|
Antiproliferative activity against human KB-VIN10 cells
|
Homo sapiens
|
90.1
nM
|
|
|
Antiproliferative activity against human KB-S15 cells
|
Homo sapiens
|
17.6
nM
|
|
|
Antiproliferative activity against human KB-7d cells
|
Homo sapiens
|
1.2
nM
|
|
|
Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
|
Homo sapiens
|
2.32
nM
|
|
|
Antiproliferative activity against taxol-resistant human A2780 cells after 48 hrs by SRB method
|
Homo sapiens
|
930.0
nM
|
|
|
Antiproliferative activity against cis-platinum-resistant human A549 cells after 48 hrs by SRB method
|
Homo sapiens
|
56.0
nM
|
|
|
Cytotoxicity against human KB/VCR cells after 72 hrs by SRB method
|
Homo sapiens
|
570.0
nM
|
|
|
Inhibition of human OATP1B1-mediated [3H]estrone 3-sulfate at 100 uM after 5 mins relative to control
|
Homo sapiens
|
28.1
%
|
|
|
Inhibition of human OATP1B3-mediated [3H]CCK-8 at 100 uM after 5 mins relative to control
|
Homo sapiens
|
65.1
%
|
|
|
PubChem BioAssay. nuclear beta catenin stimulation in WNT3A conditioned C2C12 cells-IC50. (Class of assay: confirmatory)
|
None
|
4.0
nM
|
|
|
PubChem BioAssay. Increased HeLa cells with 2N DNA content-IC50. (Class of assay: confirmatory)
|
None
|
6.2
nM
|
|
|
PubChem BioAssay. Decreased HeLa cell count-IC50. (Class of assay: confirmatory)
|
None
|
6.5
nM
|
|
|
PubChem BioAssay. VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50. (Class of assay: confirmatory)
|
None
|
6.5
nM
|
|
|
PubChem BioAssay. Increased HeLa cells with 4N DNA content-IC50. (Class of assay: confirmatory)
|
None
|
5.9
nM
|
|
|
PubChem BioAssay. alkaline phosphatase stimulation in WNT3A conditioned C2C12 cells-IC50. (Class of assay: confirmatory)
|
None
|
5.1
nM
|
|
|
PubChem BioAssay. Increased chromatin condensation in HeLa cells-IC50. (Class of assay: confirmatory)
|
None
|
6.1
nM
|
|
|
Antiproliferative activity against human KB-VIN10 cells expressing P-gp170/MDR after 72 hrs by methylene blue assay
|
Homo sapiens
|
96.4
nM
|
|
|
Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
|
Homo sapiens
|
0.9
nM
|
|
|
Antiproliferative activity against human KB-S15 cells expressing P-gp170/MDR after 72 hrs by methylene blue assay
|
Homo sapiens
|
2.1
nM
|
|
|
Antiproliferative activity against human KB-7d cells expressing MRP after 72 hrs by methylene blue assay
|
Homo sapiens
|
1.5
nM
|
|
|
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
|
Homo sapiens
|
70.0
nM
|
|
|
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
|
Homo sapiens
|
20.0
nM
|
|
|
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
|
Homo sapiens
|
20.0
nM
|
|
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
Homo sapiens
|
40.0
nM
|
|
|
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
|
Homo sapiens
|
70.0
nM
|
|
|
Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay
|
Homo sapiens
|
0.87
nM
|
|
|
Cytotoxicity against human KB/VCR cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay
|
Homo sapiens
|
387.43
nM
|
|
|
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay
|
Homo sapiens
|
36.83
nM
|
|
|
Cytotoxicity against human HeLa cells after 3 days by SRB assay
|
Homo sapiens
|
15.0
nM
|
|
|
Cytotoxicity against human vincristine-sensitive KB cells assessed as cell viability after 72 hrs by MTT assay
|
Homo sapiens
|
3.3
nM
|
|
|
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
|
Homo sapiens
|
61.0
nM
|
|
|
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
|
Homo sapiens
|
98.0
nM
|
|
|
Cytotoxicity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay
|
Homo sapiens
|
26.0
nM
|
|
|
Cytotoxicity against human HCT8 cells assessed as cell viability after 48 hrs by MTT assay
|
Homo sapiens
|
350.0
nM
|
|
|
Cytotoxicity against human A2780/TAX cells assessed as growth inhibition after 48 hrs by MTT assay
|
Homo sapiens
|
168.0
nM
|
|
|
Cytotoxicity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by MTT assay
|
Homo sapiens
|
561.0
nM
|
|
|
Antiproliferative activity against African green monkey Vero cells assessed as reduction in cell viability at 100 uM after 48 hrs by SRB assay
|
Chlorocebus sabaeus
|
16.8
%
|
|
|
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
Homo sapiens
|
300.0
nM
|
|
|
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
Chlorocebus sabaeus
|
900.0
nM
|
|
|
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 24 hrs by MTT assay
|
Homo sapiens
|
800.0
nM
|
|
|
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
|
Homo sapiens
|
4.0
nM
|
|
|
Antiproliferative activity against human K562/A02 cells after 72 hrs by MTT assay
|
Homo sapiens
|
926.0
nM
|
|
|
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
|
Homo sapiens
|
36.0
nM
|
|
|
Antiproliferative activity against human KB/VCR cells after 72 hrs by MTT assay
|
Homo sapiens
|
871.0
nM
|
|
|
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
|
Homo sapiens
|
29.0
nM
|
|
|
Cytotoxicity against human SiHa cells by MTT assay
|
Homo sapiens
|
10.0
nM
|
|
|
Cytotoxicity against mouse B16F10 cells by MTT assay
|
Mus musculus
|
10.0
nM
|
|
|
Cytotoxicity against human Chang cells by MTT assay
|
Homo sapiens
|
10.0
nM
|
|
|
Cytotoxicity against human CCRF-CEM cells assessed as decrease in cell proliferation after 72 hrs by Alamar blue assay
|
Homo sapiens
|
2.13
nM
|
|
|
Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay
|
Homo sapiens
|
0.72
nM
|
|
|
Antiproliferative activity against human KB/VCR cells after 72 hrs by sulforhodamine B assay
|
Homo sapiens
|
357.51
nM
|
|
|
Cytotoxicity against human KB/S cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
Homo sapiens
|
2.0
nM
|
|
|
Inhibition of bovine brain tubulin polymerization
|
Bos taurus
|
400.0
nM
|
|
|
Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
|
Ebolavirus
|
141.0
nM
|
|
|
Antiproliferative activity against human KB cells after 72 hrs by SRB assay
|
Homo sapiens
|
0.2
nM
|
|
|
Antiproliferative activity against human KB/VCR cells after 72 hrs by SRB assay
|
Homo sapiens
|
238.7
nM
|
|
|
Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
|
Homo sapiens
|
178.0
nM
|
|
|
Cytotoxicity against human HepG2 cells by MTT assay
|
Homo sapiens
|
0.042
ug.mL-1
|
|
|
Growth inhibition of human KB/S cells after 72 hrs by MTT assay
|
Homo sapiens
|
0.3
nM
|
|
|
Antiproliferative activity against human KB cells after 48 hrs by MTT assay
|
Homo sapiens
|
0.65
nM
|
|
|
Antiproliferative activity against human KBV cells after 48 hrs by MTT assay
|
Homo sapiens
|
417.0
nM
|
|
|
Cytotoxicity against human SMMC7721 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
|
Homo sapiens
|
3.0
nM
|
|
|
Cytotoxicity against human LO2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
|
Homo sapiens
|
200.0
nM
|
|
|
Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability
|
Homo sapiens
|
0.00063
ug.mL-1
|
|
|
Cytotoxicity in human KB cells assessed as reduction in cell viability
|
Homo sapiens
|
0.46
ug.mL-1
|
|
|
Cytotoxicity against human KB cells after 48 hrs by MTT assay
|
Homo sapiens
|
0.21
nM
|
|
|
Inhibition of bovine brain microtubule polymerization incubated for 60 mins by spectrophotometric method
|
Bos taurus
|
85.0
nM
|
|
|
Cytotoxicity against human SMMC7721 cells incubated for 72 hrs by MTT assay
|
Homo sapiens
|
10.3
nM
|
|
|
Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
|
Homo sapiens
|
60.0
nM
|
|
|
Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by MTS assay
|
Homo sapiens
|
5.0
nM
|
|
|
Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by MTS assay
|
Homo sapiens
|
3.0
nM
|
|
|
Antiproliferative activity against human KBtax cells assessed as reduction in cell viability after 72 hrs by MTS assay
|
Homo sapiens
|
49.0
nM
|
|
|
Antiproliferative activity against human KB/VCR cells assessed as reduction in cell viability after 72 hrs by MTS assay
|
Homo sapiens
|
817.0
nM
|
|
|
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
|
Homo sapiens
|
21.0
nM
|
|
|
Antiproliferative activity against human KB/S cells assessed as reduction in cell growth after 72 hrs by MTT assay
|
Homo sapiens
|
0.8
nM
|
|
|
Antiproliferative activity against human KB/VJ300 cells assessed as reduction in cell growth after 72 hrs by MTT assay
|
Homo sapiens
|
800.0
nM
|
|
|
Growth inhibition of human KB/S cells after 72 hrs by MTT assay
|
Homo sapiens
|
2.4
nM
|
|
|
Cytotoxicity against mouse B16 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
Mus musculus
|
500.0
nM
|
|
|
Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
Homo sapiens
|
650.0
nM
|
|
|
Cytotoxicity against human KB/S cells after 72 hrs by MTT assay
|
Homo sapiens
|
0.4
nM
|
|
|
Antiproliferative activity against human HL60 cells incubated for 2 days by MTT assay
|
Homo sapiens
|
0.008
ug.mL-1
|
|
|
Antiproliferative activity against human A2780 cells incubated for 72 hrs by ATPlite reagent based assay
|
Homo sapiens
|
3.4
nM
|
|
|
Antiproliferative activity against D4-9-31 resistance human A2780 cells incubated for 72 hrs by ATPlite reagent based assay
|
Homo sapiens
|
3.9
nM
|
|
|
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
Homo sapiens
|
890.0
nM
|
|
|
Antiproliferative activity against human cells MCF-7 assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
Homo sapiens
|
920.0
nM
|
|
|
Cytotoxicity against human SMMC-7721 cells assessed as cell viability after 24 hrs by MTT assay
|
Homo sapiens
|
270.0
nM
|
|
|
Cytotoxicity against human L02 cells assessed as cell viability after 24 hrs by MTT assay
|
Homo sapiens
|
300.0
nM
|
|
|
Antiproliferative activity against human K562 cells incubated for 72 hrs by CCK8 method
|
Homo sapiens
|
178.0
nM
|
|
|
Cytotoxicity against human MCF-T cells assessed as cell survival measured after 72 hrs by MTT assay
|
Homo sapiens
|
435.85
nM
|
|
|
Cytotoxicity against human vincristine-sensitive KB cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
Homo sapiens
|
0.8
nM
|
|
|
Cytotoxicity against human vincristine-resistant KB cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
Homo sapiens
|
800.0
nM
|
|
