AZD9056

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Search structure


Synonyms	Azd 9056 Azd-9056 Azd9056
Status
Molecule Category	Free-form
UNII	F13K378W4L

Structure


InChI Key	HSQAARMBHJCUOK-UHFFFAOYSA-N
Smiles	O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CCCNCCCO)ccc1Cl
InChI	InChI=1S/C24H35ClN2O2/c25-22-5-4-17(3-1-6-26-7-2-8-28)12-21(22)23(29)27-16-24-13-18-9-19(14-24)11-20(10-18)15-24/h4-5,12,18-20,26,28H,1-3,6-11,13-16H2,(H,27,29)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H35ClN2O2
Molecular Weight	419.01
AlogP	4.19
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	10.0
Polar Surface Area	61.36
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	29.0

Pharmacology

Mechanism of Action	Action	Reference
P2X purinoceptor 7 antagonist	ANTAGONIST	Other Other PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel P2X receptor	-	3.5-10	-	15-130	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	3.5-10	-	15	-
Rattus norvegicus	-	4.4	-	130	-

Target Conservation


Protein: P2X purinoceptor 7 Description: P2X purinoceptor 7 Organism : Homo sapiens Q99572 ENSG00000089041

Cross References

Resources	Reference
ChEMBL	CHEMBL3545108
DrugBank	DB12594
FDA SRS	F13K378W4L
Guide to Pharmacology	7826
SureChEMBL	SCHEMBL4126642
ZINC	ZINC000034356159

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025