EcoDrugPlus


Synonyms	Foradil Formoterol
Status
Molecule Category	Free-form
ATC	R03AC13
UNII	5ZZ84GCW8B


InChI Key	BPZSYCZIITTYBL-UHFFFAOYSA-N
Smiles	COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1
InChI	InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)

Property Name	Value
Molecular Formula	C19H24N2O4
Molecular Weight	344.41
AlogP	2.22
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	4.0
Number of Rotational Bond	9.0
Polar Surface Area	90.82
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	25.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	0.19-86	0.4-0.4	2.512	2.6-319	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	0.3162-1.585	0.4-1.4	-	-	-
Homo sapiens	0.19-86	-	2.512	2.6-319	-

Resources	Reference
ChEBI	63082
ChEMBL	CHEMBL1256786
DrugBank	DB00983
DrugCentral	1239
FDA SRS	5ZZ84GCW8B
Human Metabolome Database	HMDB0015118
Guide to Pharmacology	3465
KEGG	C07805
PharmGKB	PA134687907
SureChEMBL	SCHEMBL349579

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

FORMOTEROL

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References