AZD0328

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Synonyms
Status
Molecule Category Free-form
UNII 2B218X5QIY

Structure

InChI Key OCKIPDMKGPYYJS-ZDUSSCGKSA-N
Smiles c1cnc2c(c1)C[C@@]1(CN3CCC1CC3)O2
InChI
InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H16N2O
Molecular Weight 216.28
AlogP 1.48
Hydrogen Bond Acceptor 3.0
Polar Surface Area 25.36
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 16.0

Pharmacology

Mechanism of Action Action Reference
Neuronal acetylcholine receptor protein alpha-7 subunit agonist AGONIST PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- - - 12 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor alpha subunit
340 - - 3-140 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor beta subunit
- - - 140 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
340 - - 3-140 -
Rattus norvegicus
- - - 5 -

Target Conservation

Protein: Neuronal acetylcholine receptor protein alpha-7 subunit
Description: Neuronal acetylcholine receptor subunit alpha-7
Organism : Homo sapiens
P36544 ENSG00000175344

Cross References

Resources Reference
ChEMBL CHEMBL2151437
DrugBank DB12145
FDA SRS 2B218X5QIY
Guide to Pharmacology 7697
SureChEMBL SCHEMBL1459640
ZINC ZINC000033961869
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